M6PR (mannose-6-phosphate receptor, cation dependent)

2007-02-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CD-M6PR,CD-MPR,MPR

Other Information

Locus ID:

NCBI: 4074
MIM: 154540
HGNC: 6752
Ensembl: ENSG00000003056

Variants:

dbSNP: 4074
ClinVar: 4074
TCGA: ENSG00000003056
COSMIC: M6PR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003056ENST00000000412P20645
ENSG00000003056ENST00000536844F5GX30
ENSG00000003056ENST00000537621H0YGT2
ENSG00000003056ENST00000539143H0YFL0
ENSG00000003056ENST00000541507F5H883
ENSG00000003056ENST00000543159F5GXE0
ENSG00000003056ENST00000543258H0YGE9
ENSG00000003056ENST00000543704H0YF90
ENSG00000003056ENST00000543845F5GXU0
ENSG00000003056ENST00000544193H0YFY9
ENSG00000003056ENST00000544245F5H4U1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
183675452008Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.62
156203512004Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster.60
180883232008SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.60
247888162014A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.25
180036382008High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.21
193456842009Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31.14
220150042011In vitro human immunodeficiency virus and sperm cell interaction mediated by the mannose receptor.11
227681872012Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.9
126977642003Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.7

Citation

Dessen P

M6PR (mannose-6-phosphate receptor, cation dependent)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46022/m6pr