MADCAM1 (mucosal vascular addressin cell adhesion molecule 1)

2016-08-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
MACAM1
FUSION GENES

Other Information

Locus ID:

NCBI: 8174
MIM: 102670
HGNC: 6765
Ensembl: ENSG00000099866

Variants:

dbSNP: 8174
ClinVar: 8174
TCGA: ENSG00000099866
COSMIC: MADCAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099866ENST00000215637Q13477
ENSG00000099866ENST00000346144Q13477
ENSG00000099866ENST00000382683Q13477
ENSG00000099866ENST00000587541U3KQ59
ENSG00000099866ENST00000613880A0A087WXC9
ENSG00000099866ENST00000617201A0A087X1M5
ENSG00000099866ENST00000619333A0A087X1F1
ENSG00000099866ENST00000621286A0A087X0U8
ENSG00000099866ENST00000622462A0A087WWC0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121005192002Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease.31
183088602008CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.20
117053882001Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction.18
154832242005Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells.17
191575002009Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood.9
259085212016Development and validation of receptor occupancy pharmacodynamic assays used in the clinical development of the monoclonal antibody vedolizumab.8
118072472002A reassessment of the MAdCAM-1 structure and its role in integrin recognition.7
212968882011The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7.7
261241822015Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells.7
167505862006Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis.6

Citation

Dessen P

MADCAM1 (mucosal vascular addressin cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55892/madcam1