MAFF (MAF bZIP transcription factor F)

2003-12-01  

Identity

HGNC
MAFF
LOCATION
22q13.1
LOCUSID
23764
ALIAS
U-MAF,hMafF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23764
MIM: 604877
HGNC: 6780
Ensembl: ENSG00000185022

Variants:

dbSNP: 23764
ClinVar: 23764
TCGA: ENSG00000185022
COSMIC: MAFF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185022ENST00000338483Q9ULX9
ENSG00000185022ENST00000407965Q9ULX9
ENSG00000185022ENST00000417948B0QY70
ENSG00000185022ENST00000426621Q9ULX9
ENSG00000185022ENST00000441709B0QY71
ENSG00000185022ENST00000538320Q9ULX9
ENSG00000185022ENST00000538999Q9ULX9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
163715912006Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells.13
241184572014Small MAF genes variants and chronic myeloid leukemia.7
124902812002Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.4
165490562006The novel human gene MIP functions as a co-activator of hMafF.2
297572602018Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion.2
197235442009Establish a recombinant yeast detection system to study the effect of MIP on transactivation function of hMafF in US2-driven gene transcription.0

Citation

Dessen P

MAFF (MAF bZIP transcription factor F)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41237/maff