MAGEA2 (MAGE family member A2)

2003-06-01 Affiliation

Identity

HGNC

MAGEA2

LOCATION

Xq28

LOCUSID

4101

ALIAS

CT1.2,MAGE2,MAGEA2A

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4101
MIM: 300173
HGNC: 6800
Ensembl: ENSG00000268606

Variants:

dbSNP: 4101
ClinVar: 4101
TCGA: ENSG00000268606
COSMIC: MAGEA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000268606	ENST00000595583	P43356
ENSG00000268606	ENST00000595583	A0A024RC17
ENSG00000268606	ENST00000598543	P43356
ENSG00000268606	ENST00000598543	A0A024RC17
ENSG00000268606	ENST00000611557	P43356
ENSG00000268606	ENST00000611557	A0A024RC17
ENSG00000268606	ENST00000611674	P43356
ENSG00000268606	ENST00000611674	A0A024RC17
ENSG00000268606	ENST00000617505	E7ENJ0
ENSG00000268606	ENST00000617846	A0A087WZT8
ENSG00000268606	ENST00000620710	P43356
ENSG00000268606	ENST00000620710	A0A024RC17
ENSG00000268606	ENST00000623438	P43356
ENSG00000268606	ENST00000623438	A0A024RC17
ENSG00000268606	ENST00000623806	P43356
ENSG00000268606	ENST00000623806	A0A024RC17

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
16847267	2006	MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.	85
22117195	2012	MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.	23
17634428	2007	Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.	21
24662835	2014	Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer.	14
26001071	2015	MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4.	14
18197853	2008	Expression of melanoma-associated antigens in oral squamous cell carcinoma.	7
21422315	2011	The role of MAGEA2 in head and neck cancer.	7
22134685	2012	MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.	7
24481586	2014	The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM.	5
28415749	2017	hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways.	3

Citation

Dessen P

MAGEA2 (MAGE family member A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41245/magea2