MAGED1 (MAGE family member D1)

2003-06-01  

Identity

HGNC
LOCATION
Xp11.22
LOCUSID
ALIAS
DLXIN-1,NRAGE
FUSION GENES

Other Information

Locus ID:

NCBI: 9500
MIM: 300224
HGNC: 6813
Ensembl: ENSG00000179222

Variants:

dbSNP: 9500
ClinVar: 9500
TCGA: ENSG00000179222
COSMIC: MAGED1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179222ENST00000326587Q9Y5V3
ENSG00000179222ENST00000375695Q9Y5V3
ENSG00000179222ENST00000375722Q9Y5V3
ENSG00000179222ENST00000375772Q9Y5V3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889

References

Pubmed IDYearTitleCitations
119598512002A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
174887772007NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.23
196392182009MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells.18
150940622004hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation.14
247106242014NRAGE promotes cell proliferation by stabilizing PCNA in a ubiquitin-proteasome pathway in esophageal carcinomas.14
151625112004Comparative expression analysis of the MAGED genes during embryogenesis and brain development.12
201003152010A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.12
159302932005BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.11
161256722005Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion.10

Citation

Dessen P

MAGED1 (MAGE family member D1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41261/maged1