MAN1A1 (mannosidase alpha class 1A member 1)

2014-08-01  

Identity

HGNC
LOCATION
6q22.31
LOCUSID
ALIAS
HUMM3,HUMM9,MAN9
FUSION GENES

Other Information

Locus ID:

NCBI: 4121
MIM: 604344
HGNC: 6821
Ensembl: ENSG00000111885

Variants:

dbSNP: 4121
ClinVar: 4121
TCGA: ENSG00000111885
COSMIC: MAN1A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111885ENST00000368468P33908

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycan precursor trimmingKEGGhsa_M00073
N-glycan precursor trimmingKEGGM00073
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan trimming and elongation in the cis-GolgiREACTOMER-HSA-964739
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2REACTOMER-HSA-964827
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177278182007Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases.34
192583932009The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.22
182174162007Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.5
215771422011Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells.5
287826252017Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.2
239110472013Lysosomal exoglycosidases in nasal polyps.0
316593042019Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation.0

Citation

Dessen P

MAN1A1 (mannosidase alpha class 1A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54440/man1a1