| Alias (NCBI) | ERMAN1 |
| ERManI |
| MANA-ER |
| MRT15 |
| HGNC (Hugo) |
MAN1B1 |
| HGNC Alias symb | MANA-ER |
| MRT15 |
| ERManI |
| HGNC Alias name | endoplasmic reticulum alpha-mannosidase 1 |
| alpha 1,2-mannosidase |
| endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1 |
| ER alpha 1,2-mannosidase |
| Man9GlcNAc2-specific processing alpha-mannosidase |
| endoplasmic Reticulum Class I alpha-mannosidase |
| HGNC Previous name | mannosidase, alpha, class 1B, member 1 |
| LocusID (NCBI) |
11253 |
| Atlas_Id |
46290 |
| Location |
9q34.3 [Link to chromosome band 9q34] |
| Location_base_pair |
Starts at 137086985 and ends at 137109183 bp from pter ( according to hg38-Dec_2013) |
| Nomenclature |
|---|
| HGNC (Hugo) | MAN1B1 6823 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MAN1B1 11253 mannosidase alpha class 1B member 1 |
| Aliases | ERMAN1; ERManI; MANA-ER; MRT15 |
| GeneCards (Weizmann) | MAN1B1 |
| Ensembl hg19 (Hinxton) | ENSG00000177239 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000177239 [Gene_View] ENSG00000177239 [Sequence] chr9:137086985-137109183 [Contig_View] MAN1B1 [Vega] |
| ICGC DataPortal | ENSG00000177239 |
| TCGA cBioPortal | MAN1B1 |
| AceView (NCBI) | MAN1B1 |
| Genatlas (Paris) | MAN1B1 |
| WikiGenes | 11253 |
| SOURCE (Princeton) | MAN1B1 |
| Genetics Home Reference (NIH) | MAN1B1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MAN1B1 - chr9:137086985-137109183 + 9q34.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MAN1B1 - 9q34.3 [Description] (hg19-Feb_2009) |
| GoldenPath | MAN1B1 - 9q34.3 [CytoView hg19] MAN1B1 - 9q34.3 [CytoView hg38] |
| ImmunoBase | ENSG00000177239 |
| genome Data Viewer NCBI | MAN1B1 [Mapview hg19] |
| OMIM | 604346 614202 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB209276 AF145732 AF148509 AI312031 AK074559 |
| RefSeq transcript (Entrez) | NM_016219 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MAN1B1 |
| Alternative Splicing Gallery | ENSG00000177239 |
| Gene Expression | MAN1B1 [ NCBI-GEO ] MAN1B1 [ EBI - ARRAY_EXPRESS ]
MAN1B1 [ SEEK ] MAN1B1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MAN1B1 [ Firebrowse - Broad ] |
| Genevisible | Expression of MAN1B1 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 11253 |
| GTEX Portal (Tissue expression) | MAN1B1 |
| Human Protein Atlas | ENSG00000177239-MAN1B1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9UKM7 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9UKM7 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9UKM7 |
| Splice isoforms : SwissVar | Q9UKM7 |
| PhosPhoSitePlus | Q9UKM7 |
| Domains : Interpro (EBI) | 6hp_glycosidase-like_sf Glyco_hydro_47 Seven-hairpin_glycosidases |
| Domain families : Pfam (Sanger) | Glyco_hydro_47 (PF01532) |
| Domain families : Pfam (NCBI) | pfam01532 |
| Conserved Domain (NCBI) | MAN1B1 |
| DMDM Disease mutations | 11253 |
| Blocks (Seattle) | MAN1B1 |
| PDB (RSDB) | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| PDB Europe | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| PDB (PDBSum) | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| PDB (IMB) | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| Structural Biology KnowledgeBase | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| SCOP (Structural Classification of Proteins) | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| CATH (Classification of proteins structures) | 1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7 |
| Superfamily | Q9UKM7 |
| Human Protein Atlas [tissue] | ENSG00000177239-MAN1B1 [tissue] |
| Peptide Atlas | Q9UKM7 |
| HPRD | 05068 |
| IPI | IPI00008207 IPI00383856 IPI00556490 IPI00470859 IPI01022404 IPI01021034 IPI01014739 IPI01011077 IPI01011486 IPI01011816 IPI01012245 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9UKM7 |
| IntAct (EBI) | Q9UKM7 |
| FunCoup | ENSG00000177239 |
| BioGRID | MAN1B1 |
| STRING (EMBL) | MAN1B1 |
| ZODIAC | MAN1B1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9UKM7 |
| Ontology : AmiGO | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein glycosylation N-glycan processing oligosaccharide metabolic process membrane membrane membrane integral component of membrane ubiquitin-dependent ERAD pathway ubiquitin-dependent ERAD pathway protein alpha-1,2-demannosylation protein alpha-1,2-demannosylation trimming of terminal mannose on B branch trimming of terminal mannose on B branch trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch endoplasmic reticulum quality control compartment endoplasmic reticulum quality control compartment extracellular vesicle endoplasmic reticulum mannose trimming mannose trimming involved in glycoprotein ERAD pathway mannose trimming involved in glycoprotein ERAD pathway |
| Ontology : EGO-EBI | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein glycosylation N-glycan processing oligosaccharide metabolic process membrane membrane membrane integral component of membrane ubiquitin-dependent ERAD pathway ubiquitin-dependent ERAD pathway protein alpha-1,2-demannosylation protein alpha-1,2-demannosylation trimming of terminal mannose on B branch trimming of terminal mannose on B branch trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch endoplasmic reticulum quality control compartment endoplasmic reticulum quality control compartment extracellular vesicle endoplasmic reticulum mannose trimming mannose trimming involved in glycoprotein ERAD pathway mannose trimming involved in glycoprotein ERAD pathway |
| Pathways : KEGG | N-Glycan biosynthesis Protein processing in endoplasmic reticulum |
| NDEx Network | MAN1B1 |
| Atlas of Cancer Signalling Network | MAN1B1 |
| Wikipedia pathways | MAN1B1 |
| Orthology - Evolution |
|---|
| OrthoDB | 11253 |
| GeneTree (enSembl) | ENSG00000177239 |
| Phylogenetic Trees/Animal Genes : TreeFam | MAN1B1 |
| HOGENOM | Q9UKM7 |
| Homologs : HomoloGene | MAN1B1 |
| Homology/Alignments : Family Browser (UCSC) | MAN1B1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | MAN1B1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MAN1B1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MAN1B1 |
| dbVar | MAN1B1 |
| ClinVar | MAN1B1 |
| 1000_Genomes | MAN1B1 |
| Exome Variant Server | MAN1B1 |
| GNOMAD Browser | ENSG00000177239 |
| Varsome Browser | MAN1B1 |
| Genetic variants : HAPMAP | 11253 |
| Genomic Variants (DGV) | MAN1B1 [DGVbeta] |
| DECIPHER | MAN1B1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MAN1B1 |
| Mutations |
|---|
| ICGC Data Portal | MAN1B1 |
| TCGA Data Portal | MAN1B1 |
| Broad Tumor Portal | MAN1B1 |
| OASIS Portal | MAN1B1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MAN1B1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | MAN1B1 |
| Mutations and Diseases : HGMD | MAN1B1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Mendelian genes |
| BioMuta | search MAN1B1 |
| DgiDB (Drug Gene Interaction Database) | MAN1B1 |
| DoCM (Curated mutations) | MAN1B1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MAN1B1 (select a term) |
| intoGen | MAN1B1 |
| Cancer3D | MAN1B1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 604346 614202 |
| Orphanet | 22709 11804 |
| DisGeNET | MAN1B1 |
| Medgen | MAN1B1 |
| Genetic Testing Registry | MAN1B1
|
| NextProt | Q9UKM7 [Medical] |
| TSGene | 11253 |
| GENETests | MAN1B1 |
| Target Validation | MAN1B1 |
| Huge Navigator |
MAN1B1 [HugePedia] |
| snp3D : Map Gene to Disease | 11253 |
| BioCentury BCIQ | MAN1B1 |
| ClinGen | MAN1B1 |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 11253 |
| Pharm GKB Gene | PA30572 |
| Clinical trial | MAN1B1 |
| Miscellaneous |
|---|
| canSAR (ICR) | MAN1B1 (select the gene name) |
| Harmonizome | MAN1B1 |
| DataMed Index | MAN1B1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 79 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MAN1B1 |
| EVEX | MAN1B1 |
| GoPubMed | MAN1B1 |
