Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP1B (microtubule associated protein 1B)

Identity

Alias_symbol (synonym)MAP5
PPP1R102
Other aliasFUTSCH
HGNC (Hugo) MAP1B
LocusID (NCBI) 4131
Atlas_Id 41269
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 72107268 and ends at 72209570 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COLGALT2 (1q25.3) / MAP1B (5q13.2)MAP1B (5q13.2) / C3orf67 (3p14.2)MAP1B (5q13.2) / C9orf85 (9q21.13)
MAP1B (5q13.2) / CACNA1C (12p13.33)MAP1B (5q13.2) / MAP1B (5q13.2)MAP1B (5q13.2) / RARS2 (6q15)
MAP1B (5q13.2) / SLC27A2 (15q21.2)MED13L (12q24.21) / MAP1B (5q13.2)RBM6 (3p21.31) / MAP1B (5q13.2)
SNPH (20p13) / MAP1B (5q13.2)MAP1B 5q13.2 / C3orf67 3p14.2MAP1B 5q13.2 / SLC27A2 15q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;5)(p14;q13) MAP1B/C3orf67
t(5;15)(q13;q21) MAP1B/SLC27A2

External links

Nomenclature
HGNC (Hugo)MAP1B   6836
Cards
Entrez_Gene (NCBI)MAP1B  4131  microtubule associated protein 1B
AliasesFUTSCH; MAP5; PPP1R102
GeneCards (Weizmann)MAP1B
Ensembl hg19 (Hinxton)ENSG00000131711 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131711 [Gene_View]  ENSG00000131711 [Sequence]  chr5:72107268-72209570 [Contig_View]  MAP1B [Vega]
ICGC DataPortalENSG00000131711
TCGA cBioPortalMAP1B
AceView (NCBI)MAP1B
Genatlas (Paris)MAP1B
WikiGenes4131
SOURCE (Princeton)MAP1B
Genetics Home Reference (NIH)MAP1B
Genomic and cartography
GoldenPath hg38 (UCSC)MAP1B  -     chr5:72107268-72209570 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP1B  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathMAP1B - 5q13.2 [CytoView hg19]  MAP1B - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000131711
Mapping of homologs : NCBIMAP1B [Mapview hg19]  MAP1B [Mapview hg38]
OMIM157129   
Gene and transcription
Genbank (Entrez)AF085863 AK055112 AK096273 AK125194 AK307990
RefSeq transcript (Entrez)NM_001324255 NM_005909 NM_032010
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP1B
Cluster EST : UnigeneHs.335079 [ NCBI ]
CGAP (NCI)Hs.335079
Alternative Splicing GalleryENSG00000131711
Gene ExpressionMAP1B [ NCBI-GEO ]   MAP1B [ EBI - ARRAY_EXPRESS ]   MAP1B [ SEEK ]   MAP1B [ MEM ]
Gene Expression Viewer (FireBrowse)MAP1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4131
GTEX Portal (Tissue expression)MAP1B
Human Protein AtlasENSG00000131711-MAP1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46821   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46821  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46821
Splice isoforms : SwissVarP46821
PhosPhoSitePlusP46821
Domaine pattern : Prosite (Expaxy)MAP1B_NEURAXIN (PS00230)   
Domains : Interpro (EBI)MAP1    MAP1B    MAP1B_neuraxin   
Domain families : Pfam (Sanger)MAP1B_neuraxin (PF00414)   
Domain families : Pfam (NCBI)pfam00414   
Conserved Domain (NCBI)MAP1B
DMDM Disease mutations4131
Blocks (Seattle)MAP1B
SuperfamilyP46821
Human Protein Atlas [tissue]ENSG00000131711-MAP1B [tissue]
Peptide AtlasP46821
HPRD01139
IPIIPI00008868   IPI00967349   IPI00965014   IPI00965821   IPI00966431   
Protein Interaction databases
DIP (DOE-UCLA)P46821
IntAct (EBI)P46821
FunCoupENSG00000131711
BioGRIDMAP1B
STRING (EMBL)MAP1B
ZODIACMAP1B
Ontologies - Pathways
QuickGOP46821
Ontology : AmiGOmicrotubule cytoskeleton organization  microtubule bundle formation  photoreceptor outer segment  neuron migration  actin binding  structural molecule activity  protein binding  phospholipid binding  cytosol  cytosol  microtubule  microtubule  microtubule associated complex  plasma membrane  negative regulation of microtubule depolymerization  axonogenesis  synapse assembly  microtubule binding  microtubule binding  microtubule binding  response to mechanical stimulus  response to carbohydrate  cellular process  response to inorganic substance  peripheral nervous system axon regeneration  postsynaptic density  tubulin binding  dendrite development  response to insecticide  developmental maturation  cell junction  axon  dendrite  dendrite  growth cone  regulation of microtubule depolymerization  positive regulation of microtubule polymerization  response to estradiol  negative regulation of intracellular transport  response to vitamin A  somatodendritic compartment  response to drug  cell projection  neuronal cell body  neuronal cell body  varicosity  dendritic spine  perikaryon  protein-containing complex binding  synapse  positive regulation of axon extension  mitochondrion transport along microtubule  perinuclear region of cytoplasm  axon extension  induction of synaptic plasticity by chemical substance  establishment of monopolar cell polarity  cellular response to growth factor stimulus  cellular response to peptide hormone stimulus  apical dendrite  basal dendrite  hippocampal mossy fiber  
Ontology : EGO-EBImicrotubule cytoskeleton organization  microtubule bundle formation  photoreceptor outer segment  neuron migration  actin binding  structural molecule activity  protein binding  phospholipid binding  cytosol  cytosol  microtubule  microtubule  microtubule associated complex  plasma membrane  negative regulation of microtubule depolymerization  axonogenesis  synapse assembly  microtubule binding  microtubule binding  microtubule binding  response to mechanical stimulus  response to carbohydrate  cellular process  response to inorganic substance  peripheral nervous system axon regeneration  postsynaptic density  tubulin binding  dendrite development  response to insecticide  developmental maturation  cell junction  axon  dendrite  dendrite  growth cone  regulation of microtubule depolymerization  positive regulation of microtubule polymerization  response to estradiol  negative regulation of intracellular transport  response to vitamin A  somatodendritic compartment  response to drug  cell projection  neuronal cell body  neuronal cell body  varicosity  dendritic spine  perikaryon  protein-containing complex binding  synapse  positive regulation of axon extension  mitochondrion transport along microtubule  perinuclear region of cytoplasm  axon extension  induction of synaptic plasticity by chemical substance  establishment of monopolar cell polarity  cellular response to growth factor stimulus  cellular response to peptide hormone stimulus  apical dendrite  basal dendrite  hippocampal mossy fiber  
NDEx NetworkMAP1B
Atlas of Cancer Signalling NetworkMAP1B
Wikipedia pathwaysMAP1B
Orthology - Evolution
OrthoDB4131
GeneTree (enSembl)ENSG00000131711
Phylogenetic Trees/Animal Genes : TreeFamMAP1B
HOGENOMP46821
Homologs : HomoloGeneMAP1B
Homology/Alignments : Family Browser (UCSC)MAP1B
Gene fusions - Rearrangements
Fusion : MitelmanMAP1B/C3orf67 [5q13.2/3p14.2]  
Fusion : MitelmanMAP1B/SLC27A2 [5q13.2/15q21.2]  [t(5;15)(q13;q21)]  
Fusion PortalMAP1B 5q13.2 C3orf67 3p14.2 KIRC
Fusion PortalMAP1B 5q13.2 SLC27A2 15q21.2 PRAD
Fusion : QuiverMAP1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP1B
dbVarMAP1B
ClinVarMAP1B
1000_GenomesMAP1B 
Exome Variant ServerMAP1B
ExAC (Exome Aggregation Consortium)ENSG00000131711
GNOMAD BrowserENSG00000131711
Varsome BrowserMAP1B
Genetic variants : HAPMAP4131
Genomic Variants (DGV)MAP1B [DGVbeta]
DECIPHERMAP1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP1B 
Mutations
ICGC Data PortalMAP1B 
TCGA Data PortalMAP1B 
Broad Tumor PortalMAP1B
OASIS PortalMAP1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP1B
Mutations and Diseases : HGMDMAP1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP1B
DgiDB (Drug Gene Interaction Database)MAP1B
DoCM (Curated mutations)MAP1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP1B (select a term)
intoGenMAP1B
Cancer3DMAP1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM157129   
Orphanet
DisGeNETMAP1B
MedgenMAP1B
Genetic Testing Registry MAP1B
NextProtP46821 [Medical]
TSGene4131
GENETestsMAP1B
Target ValidationMAP1B
Huge Navigator MAP1B [HugePedia]
snp3D : Map Gene to Disease4131
BioCentury BCIQMAP1B
ClinGenMAP1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4131
Chemical/Pharm GKB GenePA30581
Clinical trialMAP1B
Miscellaneous
canSAR (ICR)MAP1B (select the gene name)
DataMed IndexMAP1B
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP1B
EVEXMAP1B
GoPubMedMAP1B
iHOPMAP1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:52:29 CET 2019
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