MAP2K3 (mitogen-activated protein kinase kinase 3)

2003-05-01  

Identity

HGNC
MAP2K3
LOCATION
17p11.2
LOCUSID
5606
ALIAS
MAPKK3,MEK3,MKK3,PRKMK3,SAPKK-2,SAPKK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5606
MIM: 602315
HGNC: 6843
Ensembl: ENSG00000034152

Variants:

dbSNP: 5606
ClinVar: 5606
TCGA: ENSG00000034152
COSMIC: MAP2K3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000034152ENST00000316920P46734
ENSG00000034152ENST00000342679P46734
ENSG00000034152ENST00000342679Q6FI23
ENSG00000034152ENST00000361818P46734
ENSG00000034152ENST00000395491X6RB39
ENSG00000034152ENST00000479129J3QL77
ENSG00000034152ENST00000483928J3QL77
ENSG00000034152ENST00000496046J3QR49
ENSG00000034152ENST00000526076E9PRZ0
ENSG00000034152ENST00000527123J3KRV4
ENSG00000034152ENST00000529517E9PMA8
ENSG00000034152ENST00000613338P46734
ENSG00000034152ENST00000627447J3QL77

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Toll-like receptor signaling pathwayKEGGko04620
Fc epsilon RI signaling pathwayKEGGko04664
GnRH signaling pathwayKEGGko04912
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Toll-like receptor signaling pathwayKEGGhsa04620
Fc epsilon RI signaling pathwayKEGGhsa04664
GnRH signaling pathwayKEGGhsa04912
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
MAPK (p38) signalingKEGGhsa_M00689
MAPK (p38) signalingKEGGM00689
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of anthrax toxinsREACTOMER-HSA-5210891
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
activated TAK1 mediates p38 MAPK activationREACTOMER-HSA-450302
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated20124951
PA30594MAP3K11GenePathwayassociated23922006
PA30603MAP3K7GenePathwayassociated23922006
PA30616MAPK1GenePathwayassociated20124951
PA30617MAPK10GenePathwayassociated20124951
PA30618MAPK11GenePathwayassociated20124951
PA30619MAPK12GenePathwayassociated20124951
PA30620MAPK13GenePathwayassociated20124951
PA30621MAPK14GenePathwayassociated20124951, 23922006
PA30622MAPK3GenePathwayassociated20124951
PA30623MAPK4GenePathwayassociated20124951
PA30624MAPK6GenePathwayassociated20124951
PA30625MAPK7GenePathwayassociated20124951
PA30630MAPK9GenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
368702822023Identification of MAP Kinase Kinase 3 as a protein target of myricetin in non-small cell lung cancer cells.2
377139932023Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance.1
368702822023Identification of MAP Kinase Kinase 3 as a protein target of myricetin in non-small cell lung cancer cells.2
377139932023Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance.1
336604142021The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.11
337742142021Whole-Exome Sequencing Reveals Novel Variations in Patients with Familial Von Hippel-Lindau Syndrome.0
348300952021Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.2
336604142021The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.11
337742142021Whole-Exome Sequencing Reveals Novel Variations in Patients with Familial Von Hippel-Lindau Syndrome.0
348300952021Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.2
316345612020miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells.11
324295932020The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.8
327475572020Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation.4
328436392020TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway.5
316345612020miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells.11

Citation

Dessen P

MAP2K3 (mitogen-activated protein kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41272/map2k3