Identity
HGNC
LOCATION
15q23
LOCUSID
ALIAS
HsT17454,MAPKK5,MEK5,PRKMK5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5607
MIM: 602520
HGNC: 6845
Ensembl: ENSG00000137764
Variants:
dbSNP: 5607
ClinVar: 5607
TCGA: ENSG00000137764
COSMIC: MAP2K5
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA283 | MAPK8 | Gene | Pathway | associated | 20124951 | ||
| PA30616 | MAPK1 | Gene | Pathway | associated | 20124951 | ||
| PA30617 | MAPK10 | Gene | Pathway | associated | 20124951 | ||
| PA30618 | MAPK11 | Gene | Pathway | associated | 20124951 | ||
| PA30619 | MAPK12 | Gene | Pathway | associated | 20124951 | ||
| PA30620 | MAPK13 | Gene | Pathway | associated | 20124951 | ||
| PA30621 | MAPK14 | Gene | Pathway | associated | 20124951 | ||
| PA30622 | MAPK3 | Gene | Pathway | associated | 20124951 | ||
| PA30623 | MAPK4 | Gene | Pathway | associated | 20124951 | ||
| PA30624 | MAPK6 | Gene | Pathway | associated | 20124951 | ||
| PA30625 | MAPK7 | Gene | Pathway | associated | 20124951 | ||
| PA30630 | MAPK9 | Gene | Pathway | associated | 20124951 | ||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36968222 | 2023 | MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells. | 2 |
| 37278562 | 2023 | Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival. | 1 |
| 36968222 | 2023 | MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells. | 2 |
| 37278562 | 2023 | Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival. | 1 |
| 35713705 | 2022 | Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation. | 0 |
| 35713705 | 2022 | Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation. | 0 |
| 34245854 | 2021 | Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. | 8 |
| 34681917 | 2021 | The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. | 10 |
| 34245854 | 2021 | Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. | 8 |
| 34681917 | 2021 | The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. | 10 |
| 31969375 | 2020 | The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. | 36 |
| 33232597 | 2020 | Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults. | 0 |
| 31969375 | 2020 | The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. | 36 |
| 33232597 | 2020 | Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults. | 0 |
| 30132833 | 2019 | Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma. | 18 |
Citation
Dessen P
MAP2K5 (mitogen-activated protein kinase kinase 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41273/map2k5
