MAP3K1 (mitogen-activated protein kinase kinase kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
MAPKKK1,MEKK,MEKK
FUSION GENES

Other Information

Locus ID:

NCBI: 4214
MIM: 600982
HGNC: 6848
Ensembl: ENSG00000095015

Variants:

dbSNP: 4214
ClinVar: 4214
TCGA: ENSG00000095015
COSMIC: MAP3K1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095015ENST00000399503Q13233

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Ubiquitin mediated proteolysisKEGGko04120
Tight junctionKEGGko04530
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
Ubiquitin mediated proteolysisKEGGhsa04120
Tight junctionKEGGhsa04530
GnRH signaling pathwayKEGGhsa04912
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD21636554
PA134687924erlotinibChemicalClinicalAnnotationassociatedPD21636554
PA134913435SHC3GenePathwayassociated
PA134971076SHC2GenePathwayassociated
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD27670765
PA284MAP2K7GenePathwayassociated23922006
PA28962GRB2GenePathwayassociated
PA29444HRASGenePathwayassociated
PA30196KRASGenePathwayassociated
PA30589MAP2K4GenePathwayassociated23922006
PA30932MRASGenePathwayassociated
PA31768NRASGenePathwayassociated
PA34861RRASGenePathwayassociated
PA35746SHC1GenePathwayassociated
PA36024SOS1GenePathwayassociated
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21636554
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD27670765
PA448803carboplatinChemicalClinicalAnnotationassociatedPD21636554
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21636554
PA449383docetaxelChemicalClinicalAnnotationassociatedPD21636554
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD21636554

References

Pubmed IDYearTitleCitations
202373442010Performance of common genetic variants in breast-cancer risk models.191
184372042008Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.167
119719712002Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.138
183557722008Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.99
183557722008Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
146124082003Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.73
205547492010FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.59
206052012010Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.59
197893662009Evaluation of 11 breast cancer susceptibility loci in African-American women.56

Citation

Dessen P

MAP3K1 (mitogen-activated protein kinase kinase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43341/map3k1