Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP3K12 (mitogen-activated protein kinase kinase kinase 12)

Identity

Alias_namesZPK
Alias_symbol (synonym)MUK
DLK
ZPKP1
MEKK12
Other alias
HGNC (Hugo) MAP3K12
LocusID (NCBI) 7786
Atlas_Id 41278
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53480492 and ends at 53499660 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PACS2 (14q32.33) / MAP3K12 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP3K12   6851
Cards
Entrez_Gene (NCBI)MAP3K12  7786  mitogen-activated protein kinase kinase kinase 12
AliasesDLK; MEKK12; MUK; ZPK; 
ZPKP1
GeneCards (Weizmann)MAP3K12
Ensembl hg19 (Hinxton)ENSG00000139625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139625 [Gene_View]  ENSG00000139625 [Sequence]  chr12:53480492-53499660 [Contig_View]  MAP3K12 [Vega]
ICGC DataPortalENSG00000139625
TCGA cBioPortalMAP3K12
AceView (NCBI)MAP3K12
Genatlas (Paris)MAP3K12
WikiGenes7786
SOURCE (Princeton)MAP3K12
Genetics Home Reference (NIH)MAP3K12
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K12  -     chr12:53480492-53499660 -  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K12  -     12q13.13   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K12 - 12q13.13 [CytoView hg19]  MAP3K12 - 12q13.13 [CytoView hg38]
ImmunoBaseENSG00000139625
Mapping of homologs : NCBIMAP3K12 [Mapview hg19]  MAP3K12 [Mapview hg38]
OMIM600447   
Gene and transcription
Genbank (Entrez)AB209453 AK094195 AK314530 BC037585 BC050050
RefSeq transcript (Entrez)NM_001193511 NM_006301
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K12
Cluster EST : UnigeneHs.713539 [ NCBI ]
CGAP (NCI)Hs.713539
Alternative Splicing GalleryENSG00000139625
Gene ExpressionMAP3K12 [ NCBI-GEO ]   MAP3K12 [ EBI - ARRAY_EXPRESS ]   MAP3K12 [ SEEK ]   MAP3K12 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7786
GTEX Portal (Tissue expression)MAP3K12
Human Protein AtlasENSG00000139625-MAP3K12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12852   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12852  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12852
Splice isoforms : SwissVarQ12852
PhosPhoSitePlusQ12852
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MAP3K12_MAP3K13    MAPKKK12    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K12
DMDM Disease mutations7786
Blocks (Seattle)MAP3K12
PDB (RSDB)5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
PDB Europe5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
PDB (PDBSum)5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
PDB (IMB)5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
Structural Biology KnowledgeBase5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
SCOP (Structural Classification of Proteins)5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
CATH (Classification of proteins structures)5CEN    5CEO    5CEP    5CEQ    5VO1    5VO2   
SuperfamilyQ12852
Human Protein Atlas [tissue]ENSG00000139625-MAP3K12 [tissue]
Peptide AtlasQ12852
HPRD02709
IPIIPI00292181   IPI00555727   IPI01021678   IPI01022412   IPI00796081   
Protein Interaction databases
DIP (DOE-UCLA)Q12852
IntAct (EBI)Q12852
FunCoupENSG00000139625
BioGRIDMAP3K12
STRING (EMBL)MAP3K12
ZODIACMAP3K12
Ontologies - Pathways
QuickGOQ12852
Ontology : AmiGOMAPK cascade  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  membrane  histone phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  growth cone  intracellular signal transduction  protein homodimerization activity  positive regulation of transcription, DNA-templated  protein autophosphorylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of motor neuron apoptotic process  
Ontology : EGO-EBIMAPK cascade  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  membrane  histone phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  growth cone  intracellular signal transduction  protein homodimerization activity  positive regulation of transcription, DNA-templated  protein autophosphorylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of motor neuron apoptotic process  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP3K12
Atlas of Cancer Signalling NetworkMAP3K12
Wikipedia pathwaysMAP3K12
Orthology - Evolution
OrthoDB7786
GeneTree (enSembl)ENSG00000139625
Phylogenetic Trees/Animal Genes : TreeFamMAP3K12
HOGENOMQ12852
Homologs : HomoloGeneMAP3K12
Homology/Alignments : Family Browser (UCSC)MAP3K12
Gene fusions - Rearrangements
Fusion : QuiverMAP3K12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K12
dbVarMAP3K12
ClinVarMAP3K12
1000_GenomesMAP3K12 
Exome Variant ServerMAP3K12
ExAC (Exome Aggregation Consortium)ENSG00000139625
GNOMAD BrowserENSG00000139625
Varsome BrowserMAP3K12
Genetic variants : HAPMAP7786
Genomic Variants (DGV)MAP3K12 [DGVbeta]
DECIPHERMAP3K12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K12 
Mutations
ICGC Data PortalMAP3K12 
TCGA Data PortalMAP3K12 
Broad Tumor PortalMAP3K12
OASIS PortalMAP3K12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K12
Mutations and Diseases : HGMDMAP3K12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K12
DgiDB (Drug Gene Interaction Database)MAP3K12
DoCM (Curated mutations)MAP3K12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K12 (select a term)
intoGenMAP3K12
Cancer3DMAP3K12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600447   
Orphanet
DisGeNETMAP3K12
MedgenMAP3K12
Genetic Testing Registry MAP3K12
NextProtQ12852 [Medical]
TSGene7786
GENETestsMAP3K12
Target ValidationMAP3K12
Huge Navigator MAP3K12 [HugePedia]
snp3D : Map Gene to Disease7786
BioCentury BCIQMAP3K12
ClinGenMAP3K12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7786
Chemical/Pharm GKB GenePA30595
Clinical trialMAP3K12
Miscellaneous
canSAR (ICR)MAP3K12 (select the gene name)
DataMed IndexMAP3K12
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K12
EVEXMAP3K12
GoPubMedMAP3K12
iHOPMAP3K12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:52:32 CET 2019
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