MAP3K12 (mitogen-activated protein kinase kinase kinase 12)

2003-11-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
DLK,MEKK12,MUK,ZPK,ZPKP1
FUSION GENES

Other Information

Locus ID:

NCBI: 7786
MIM: 600447
HGNC: 6851
Ensembl: ENSG00000139625

Variants:

dbSNP: 7786
ClinVar: 7786
TCGA: ENSG00000139625
COSMIC: MAP3K12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139625ENST00000267079Q12852
ENSG00000139625ENST00000267079A0A024RAY5
ENSG00000139625ENST00000547035Q12852
ENSG00000139625ENST00000547488Q12852
ENSG00000139625ENST00000548565H3BMF0
ENSG00000139625ENST00000552365F8VUG4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189958352008DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.64
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
198519842010Genetic variation in MicroRNA genes and risk of oral premalignant lesions.39
286411132017Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.30
156111342005Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation.27
196755782010The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression.15
253411102015Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.12
156958242005The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.8
300097822018Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.8
259990172015MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function.6

Citation

Dessen P

MAP3K12 (mitogen-activated protein kinase kinase kinase 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41278/map3k12