MAP3K2 (mitogen-activated protein kinase kinase kinase 2)

2006-10-01 Affiliation

Identity

HGNC

MAP3K2

LOCATION

2q14.3

LOCUSID

10746

ALIAS

MEKK2,MEKK2B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10746
MIM: 609487
HGNC: 6854
Ensembl: ENSG00000169967

Variants:

dbSNP: 10746
ClinVar: 10746
TCGA: ENSG00000169967
COSMIC: MAP3K2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169967	ENST00000344908	Q9Y2U5
ENSG00000169967	ENST00000344908	A0A024RAH0
ENSG00000169967	ENST00000409179	F8W6K3
ENSG00000169967	ENST00000409947	Q9Y2U5
ENSG00000169967	ENST00000409947	A0A024RAH0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Gap junction	KEGG	ko04540
GnRH signaling pathway	KEGG	ko04912
MAPK signaling pathway	KEGG	hsa04010
Gap junction	KEGG	hsa04540
GnRH signaling pathway	KEGG	hsa04912
MAPK (JNK) signaling	KEGG	hsa_M00688
MAPK (p38) signaling	KEGG	hsa_M00689
MAPK (ERK5) signaling	KEGG	hsa_M00690
MAPK (JNK) signaling	KEGG	M00688
MAPK (p38) signaling	KEGG	M00689
MAPK (ERK5) signaling	KEGG	M00690

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
24847881	2014	SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.	120
19690195	2009	Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue.	59
22139075	2012	Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.	32
14734742	2004	Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.	30
25012295	2014	EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells.	23
15988011	2005	Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.	19
18761086	2008	XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.	19
19289468	2009	MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.	19
15075238	2004	MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.	15
25304384	2014	The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.	15

Citation

Dessen P

MAP3K2 (mitogen-activated protein kinase kinase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43343/map3k2