MAP3K20 (mitogen-activated protein kinase kinase kinase 20)

2016-12-01  

Identity

HGNC
MAP3K20
LOCATION
2q31.1
LOCUSID
51776
ALIAS
AZK,CNM6,MLK7,MLT,MLTK,MLTKalpha,MLTKbeta,MRK,SFMMP,ZAK,mlklak,pk

Other Information

Locus ID:

NCBI: 51776
MIM: 609479
HGNC: 17797
Ensembl: ENSG00000091436

Variants:

dbSNP: 51776
ClinVar: 51776
TCGA: ENSG00000091436
COSMIC: MAP3K20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091436ENST00000338983Q9NYL2
ENSG00000091436ENST00000338983D4Q8H0
ENSG00000091436ENST00000375213Q9NYL2
ENSG00000091436ENST00000409176Q9NYL2
ENSG00000091436ENST00000422149C9J3F7
ENSG00000091436ENST00000539448Q9NYL2
ENSG00000091436ENST00000539448D4Q8H0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
183315922008ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.43
250133762014Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma.41
248072152014Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.34
157379972005Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.21
203316272010ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.14
265227282016The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer.13
153426222004The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.12
241707692014Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.11
267556362016Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.9

Citation

Dessen P

MAP3K20 (mitogen-activated protein kinase kinase kinase 20)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56651/map3k20