MAP3K4 (mitogen-activated protein kinase kinase kinase 4)

2003-11-01  

Identity

HGNC
MAP3K4
LOCATION
6q26
LOCUSID
4216
ALIAS
MAPKKK4,MEKK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4216
MIM: 602425
HGNC: 6856
Ensembl: ENSG00000085511

Variants:

dbSNP: 4216
ClinVar: 4216
TCGA: ENSG00000085511
COSMIC: MAP3K4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085511ENST00000348824J3KNB8
ENSG00000085511ENST00000366919Q9Y6R4
ENSG00000085511ENST00000366920F5H538
ENSG00000085511ENST00000392142Q9Y6R4
ENSG00000085511ENST00000448119F5H534
ENSG00000085511ENST00000490904F5H1X6
ENSG00000085511ENST00000542952F5H2S6
ENSG00000085511ENST00000544041F5H4R1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
GnRH signaling pathwayKEGGhsa04912
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174969142007Role of mitogen-activated protein kinase kinase 4 in cancer.51
223098392012Association study of 45 candidate genes in nicotine dependence in Han Chinese.25
251737552014Integrative identification of Epstein-Barr virus-associated mutations and epigenetic alterations in gastric cancer.25
206241542010Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.20
161576002005MEKK4 is an effector of the embryonic TRAF4 for JNK activation.19
128786102003Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.15
202214032010Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.14
237603662013The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.12
240362112014HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).11
244523332014Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.10

Citation

Dessen P

MAP3K4 (mitogen-activated protein kinase kinase kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41281/map3k4