MAP3K6 (mitogen-activated protein kinase kinase kinase 6)

2006-10-01  

Identity

HGNC
MAP3K6
LOCATION
1p36.11
LOCUSID
9064
ALIAS
ASK2,MAPKKK6,MEKK6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9064
MIM: 604468
HGNC: 6858
Ensembl: ENSG00000142733

Variants:

dbSNP: 9064
ClinVar: 9064
TCGA: ENSG00000142733
COSMIC: MAP3K6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142733ENST00000357582O95382
ENSG00000142733ENST00000374040O95382
ENSG00000142733ENST00000486046H0Y8A3
ENSG00000142733ENST00000659880A0A590UJN3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
172105792007Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.37
253405222014Germline mutations in MAP3K6 are associated with familial gastric cancer.21
183275632008ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
192466382009Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.10
262431922015The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.5
293303372018Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility.5

Citation

Dessen P

MAP3K6 (mitogen-activated protein kinase kinase kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43344/map3k6