Identity
HGNC
LOCATION
2p22.1
LOCUSID
ALIAS
GLK,MAPKKKK3,MEKKK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8491
MIM: 604921
HGNC: 6865
Ensembl: ENSG00000011566
Variants:
dbSNP: 8491
ClinVar: 8491
TCGA: ENSG00000011566
COSMIC: MAP4K3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK signaling pathway | KEGG | ko04010 |
| MAPK signaling pathway | KEGG | hsa04010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34610951 | 2022 | Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. | 4 |
| 34610951 | 2022 | Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. | 4 |
| 31578840 | 2021 | MiR-338-3p inhibits growth of glioblastoma through targeting MAP4K3. | 6 |
| 31578840 | 2021 | MiR-338-3p inhibits growth of glioblastoma through targeting MAP4K3. | 6 |
| 30904818 | 2019 | Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma. | 19 |
| 31318609 | 2019 | AhR-ROR-γt complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus. | 17 |
| 31431460 | 2019 | MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1. | 25 |
| 30904818 | 2019 | Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma. | 19 |
| 31318609 | 2019 | AhR-ROR-γt complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus. | 17 |
| 31431460 | 2019 | MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1. | 25 |
| 29507340 | 2018 | MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. | 58 |
| 29507340 | 2018 | MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. | 58 |
| 27727493 | 2017 | Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension. | 6 |
| 28099144 | 2017 | MiR-199a-5p and let-7c cooperatively inhibit migration and invasion by targeting MAP4K3 in hepatocellular carcinoma. | 19 |
| 27727493 | 2017 | Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension. | 6 |
Citation
Dessen P
MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41286/map4k3
