MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

2003-11-01  

Identity

HGNC
MAP4K4
LOCATION
2q11.2
LOCUSID
9448
ALIAS
FLH21957,HEL-S-31,HGK,MEKKK4,NIK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9448
MIM: 604666
HGNC: 6866
Ensembl: ENSG00000071054

Variants:

dbSNP: 9448
ClinVar: 9448
TCGA: ENSG00000071054
COSMIC: MAP4K4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071054ENST00000302217C9J840
ENSG00000071054ENST00000324219G5E948
ENSG00000071054ENST00000347699O95819
ENSG00000071054ENST00000350198G3XAA2
ENSG00000071054ENST00000413150E7ENQ1
ENSG00000071054ENST00000417294H7C360
ENSG00000071054ENST00000418101H7C3Z6
ENSG00000071054ENST00000421882H7C0P6
ENSG00000071054ENST00000425019E7EN19
ENSG00000071054ENST00000427603E7ETN6
ENSG00000071054ENST00000456652E7EX83
ENSG00000071054ENST00000625522A0A0D9SEY1
ENSG00000071054ENST00000627726A0A0D9SG62

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotationassociatedPD
PA449563exemestaneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
165374542006A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.71
172277682007MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.52
126120792003The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.45
149661412004Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.40
257999962015MAP4K4 regulates integrin-FERM binding to control endothelial cell motility.40
189810012008Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma.39
242338382014SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells.39
211964142011ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth.34
196901742009Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.24
228241482012Expression and prognostic significance of MAP4K4 in lung adenocarcinoma.21

Citation

Dessen P

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41287/map4k4