Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Identity

Alias_symbol (synonym)HGK
NIK
FLH21957
Other aliasHEL-S-31
MEKKK4
HGNC (Hugo) MAP4K4
LocusID (NCBI) 9448
Atlas_Id 41287
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 101698076 and ends at 101894690 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC59 (17q21.33) / MAP4K4 (2q11.2)MAP4K4 (2q11.2) / ASH1L (1q22)MAP4K4 (2q11.2) / MAP4K4 (2q11.2)
MAP4K4 (2q11.2) / MUCL1 (12q13.2)MAP4K4 (2q11.2) / PPM1A (14q23.1)NCL (2q37.1) / MAP4K4 (2q11.2)
P4HB (17q25.3) / MAP4K4 (2q11.2)PKP4 (2q24.1) / MAP4K4 (2q11.2)PPP2R5E (14q23.2) / MAP4K4 (2q11.2)
MAP4K4 2q11.2 / MUCL1 12q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;12)(q11;q13) MAP4K4/MUCL1

External links

Nomenclature
HGNC (Hugo)MAP4K4   6866
Cards
Entrez_Gene (NCBI)MAP4K4  9448  mitogen-activated protein kinase kinase kinase kinase 4
AliasesFLH21957; HEL-S-31; HGK; MEKKK4; 
NIK
GeneCards (Weizmann)MAP4K4
Ensembl hg19 (Hinxton)ENSG00000071054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071054 [Gene_View]  ENSG00000071054 [Sequence]  chr2:101698076-101894690 [Contig_View]  MAP4K4 [Vega]
ICGC DataPortalENSG00000071054
TCGA cBioPortalMAP4K4
AceView (NCBI)MAP4K4
Genatlas (Paris)MAP4K4
WikiGenes9448
SOURCE (Princeton)MAP4K4
Genetics Home Reference (NIH)MAP4K4
Genomic and cartography
GoldenPath hg38 (UCSC)MAP4K4  -     chr2:101698076-101894690 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP4K4  -     2q11.2   [Description]    (hg19-Feb_2009)
GoldenPathMAP4K4 - 2q11.2 [CytoView hg19]  MAP4K4 - 2q11.2 [CytoView hg38]
ImmunoBaseENSG00000071054
Mapping of homologs : NCBIMAP4K4 [Mapview hg19]  MAP4K4 [Mapview hg38]
OMIM604666   
Gene and transcription
Genbank (Entrez)AB013385 AB014587 AF096300 AK000380 AK001272
RefSeq transcript (Entrez)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP4K4
Cluster EST : UnigeneHs.701013 [ NCBI ]
CGAP (NCI)Hs.701013
Alternative Splicing GalleryENSG00000071054
Gene ExpressionMAP4K4 [ NCBI-GEO ]   MAP4K4 [ EBI - ARRAY_EXPRESS ]   MAP4K4 [ SEEK ]   MAP4K4 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9448
GTEX Portal (Tissue expression)MAP4K4
Human Protein AtlasENSG00000071054-MAP4K4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95819   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95819  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95819
Splice isoforms : SwissVarO95819
PhosPhoSitePlusO95819
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K4
DMDM Disease mutations9448
Blocks (Seattle)MAP4K4
PDB (RSDB)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
PDB Europe4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
PDB (PDBSum)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
PDB (IMB)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
Structural Biology KnowledgeBase4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
SCOP (Structural Classification of Proteins)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
CATH (Classification of proteins structures)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95   
SuperfamilyO95819
Human Protein Atlas [tissue]ENSG00000071054-MAP4K4 [tissue]
Peptide AtlasO95819
HPRD05235
IPIIPI00006752   IPI00219800   IPI00639883   IPI00219802   IPI00927735   IPI00015777   IPI01021877   IPI01020880   IPI00604647   IPI00219799   IPI00952975   IPI00924942   
Protein Interaction databases
DIP (DOE-UCLA)O95819
IntAct (EBI)O95819
FunCoupENSG00000071054
BioGRIDMAP4K4
STRING (EMBL)MAP4K4
ZODIACMAP4K4
Ontologies - Pathways
QuickGOO95819
Ontology : AmiGOMAPK cascade  negative regulation of cell-matrix adhesion  creatine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  focal adhesion  protein phosphorylation  microtubule binding  signal transduction by protein phosphorylation  microvillus assembly  positive regulation of cell migration  stress-activated protein kinase signaling cascade  positive regulation of ARF protein signal transduction  activation of protein kinase activity  intracellular signal transduction  negative regulation of apoptotic process  positive regulation of GTPase activity  regulation of JNK cascade  neuron projection morphogenesis  positive regulation of keratinocyte migration  positive regulation of focal adhesion assembly  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of neuron projection regeneration  positive regulation of adherens junction organization  
Ontology : EGO-EBIMAPK cascade  negative regulation of cell-matrix adhesion  creatine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  focal adhesion  protein phosphorylation  microtubule binding  signal transduction by protein phosphorylation  microvillus assembly  positive regulation of cell migration  stress-activated protein kinase signaling cascade  positive regulation of ARF protein signal transduction  activation of protein kinase activity  intracellular signal transduction  negative regulation of apoptotic process  positive regulation of GTPase activity  regulation of JNK cascade  neuron projection morphogenesis  positive regulation of keratinocyte migration  positive regulation of focal adhesion assembly  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of neuron projection regeneration  positive regulation of adherens junction organization  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K4
Atlas of Cancer Signalling NetworkMAP4K4
Wikipedia pathwaysMAP4K4
Orthology - Evolution
OrthoDB9448
GeneTree (enSembl)ENSG00000071054
Phylogenetic Trees/Animal Genes : TreeFamMAP4K4
HOGENOMO95819
Homologs : HomoloGeneMAP4K4
Homology/Alignments : Family Browser (UCSC)MAP4K4
Gene fusions - Rearrangements
Fusion : MitelmanMAP4K4/MUCL1 [2q11.2/12q13.2]  
Fusion PortalMAP4K4 2q11.2 MUCL1 12q13.2 LUAD
Fusion : QuiverMAP4K4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K4
dbVarMAP4K4
ClinVarMAP4K4
1000_GenomesMAP4K4 
Exome Variant ServerMAP4K4
ExAC (Exome Aggregation Consortium)ENSG00000071054
GNOMAD BrowserENSG00000071054
Varsome BrowserMAP4K4
Genetic variants : HAPMAP9448
Genomic Variants (DGV)MAP4K4 [DGVbeta]
DECIPHERMAP4K4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP4K4 
Mutations
ICGC Data PortalMAP4K4 
TCGA Data PortalMAP4K4 
Broad Tumor PortalMAP4K4
OASIS PortalMAP4K4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP4K4
Mutations and Diseases : HGMDMAP4K4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP4K4
DgiDB (Drug Gene Interaction Database)MAP4K4
DoCM (Curated mutations)MAP4K4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K4 (select a term)
intoGenMAP4K4
Cancer3DMAP4K4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604666   
Orphanet
DisGeNETMAP4K4
MedgenMAP4K4
Genetic Testing Registry MAP4K4
NextProtO95819 [Medical]
TSGene9448
GENETestsMAP4K4
Target ValidationMAP4K4
Huge Navigator MAP4K4 [HugePedia]
snp3D : Map Gene to Disease9448
BioCentury BCIQMAP4K4
ClinGenMAP4K4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9448
Chemical/Pharm GKB GenePA30612
Clinical trialMAP4K4
Miscellaneous
canSAR (ICR)MAP4K4 (select the gene name)
DataMed IndexMAP4K4
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP4K4
EVEXMAP4K4
GoPubMedMAP4K4
iHOPMAP4K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:52:36 CET 2019
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