MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)

2006-10-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
GCKR,KHS,KHS1,MAPKKKK5
FUSION GENES

Other Information

Locus ID:

NCBI: 11183
MIM: 604923
HGNC: 6867
Ensembl: ENSG00000012983

Variants:

dbSNP: 11183
ClinVar: 11183
TCGA: ENSG00000012983
COSMIC: MAP4K5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000012983ENST00000013125Q9Y4K4
ENSG00000012983ENST00000554091G3V4Q4
ENSG00000012983ENST00000554273G3V3V7
ENSG00000012983ENST00000555216G3V5C6
ENSG00000012983ENST00000557390G3V4T8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125919262003Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).58
270236252016Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer.8
166997252006The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai.2

Citation

Dessen P

MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43348/map4k5