MAP7D3 (MAP7 domain containing 3)

2015-05-01  

Identity

HGNC
LOCATION
Xq26.3
LOCUSID
ALIAS
MDP3
FUSION GENES

Other Information

Locus ID:

NCBI: 79649
MIM: 300930
HGNC: 25742
Ensembl: ENSG00000129680

Variants:

dbSNP: 79649
ClinVar: 79649
TCGA: ENSG00000129680
COSMIC: MAP7D3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129680ENST00000316077Q8IWC1
ENSG00000129680ENST00000370660A0A0A0MRP0
ENSG00000129680ENST00000370661Q8IWC1
ENSG00000129680ENST00000370663Q8IWC1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
251617032014Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis.14
221429022011Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.13
307704342019MAP7 family proteins regulate kinesin-1 recruitment and activation.10
246145952014Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.8
249275012014C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin.5
272840042016DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.4

Citation

Dessen P

MAP7D3 (MAP7 domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55197/map7d3