MAPRE2 (microtubule associated protein RP/EB family member 2)

2003-02-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
CSCSC2,EB1,EB2,RP1
FUSION GENES

Other Information

Locus ID:

NCBI: 10982
MIM: 605789
HGNC: 6891
Ensembl: ENSG00000166974

Variants:

dbSNP: 10982
ClinVar: 10982
TCGA: ENSG00000166974
COSMIC: MAPRE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166974ENST00000300249Q15555
ENSG00000166974ENST00000300249A0A024RC33
ENSG00000166974ENST00000413393Q15555
ENSG00000166974ENST00000436190Q15555
ENSG00000166974ENST00000538170Q15555
ENSG00000166974ENST00000587359K7ENB3
ENSG00000166974ENST00000588349M0QX52
ENSG00000166974ENST00000588910Q15555
ENSG00000166974ENST00000589180K7EL66
ENSG00000166974ENST00000589699Q15555
ENSG00000166974ENST00000591734K7ERD8

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178896702007Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.120
124759542002EB1 targets to kinetochores with attached, polymerizing microtubules.73
167635652006Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.71
123887622002Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
180813192008Suppression of microtubule dynamic instability by the +TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued.34
200083242010Molecular insights into mammalian end-binding protein heterodimerization.26
160071682005Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway.25
173500422007Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability.23
197788972009Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior.20

Citation

Dessen P

MAPRE2 (microtubule associated protein RP/EB family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41297/mapre2