MARCHF5 (membrane associated ring-CH-type finger 5)

2019-08-01  

Identity

HGNC
MARCHF5
LOCATION
10q23.32
LOCUSID
54708
ALIAS
MARCH-V,MARCH5,MITOL,RNF153

Other Information

Locus ID:

NCBI: 54708
MIM: 610637
HGNC: 26025
Ensembl: ENSG00000198060

Variants:

dbSNP: 54708
ClinVar: 54708
TCGA: ENSG00000198060
COSMIC: MARCHF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198060ENST00000358935Q9NX47

References

Pubmed IDYearTitleCitations
176068672007The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division.184
169366362006MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.161
168743012006A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.141
237270172013MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.83
201035332010Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1.75
262461712015The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling.39
197410962009Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.35
265647962016Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.35
281047342017Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.35
247222972014MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival.34

Citation

Dessen P

MARCHF5 (membrane associated ring-CH-type finger 5)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58113/marchf5