MARCHF8 (membrane associated ring-CH-type finger 8)

2019-08-01  

Identity

HGNC
LOCATION
10q11.21
LOCUSID
ALIAS
CMIR,MARCH-VIII,MARCH8,MIR,RNF178,c-MIR

Other Information

Locus ID:

NCBI: 220972
MIM: 613335
HGNC: 23356
Ensembl: ENSG00000165406

Variants:

dbSNP: 220972
ClinVar: 220972
TCGA: ENSG00000165406
COSMIC: MARCHF8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165406ENST00000319836Q5T0T0
ENSG00000165406ENST00000319836A0A024R7U2
ENSG00000165406ENST00000395769Q5T0T0
ENSG00000165406ENST00000395769A0A024R7U2
ENSG00000165406ENST00000453424Q5T0T0
ENSG00000165406ENST00000453980A0A0A0MSM7

References

Pubmed IDYearTitleCitations
217528292011Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.263
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
125821532003c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.59
217575422011MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.43
265239722015MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.34
229041872012The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.32
233000752013Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.24
211519972010Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.23
236067472013Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.18

Citation

Dessen P

MARCHF8 (membrane associated ring-CH-type finger 8)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58101/marchf8