MARCO (macrophage receptor with collagenous structure)

2017-10-01  

Identity

HGNC
MARCO
LOCATION
2q14.2
LOCUSID
8685
ALIAS
SCARA2,SR-A6

Other Information

Locus ID:

NCBI: 8685
MIM: 604870
HGNC: 6895
Ensembl: ENSG00000019169

Variants:

dbSNP: 8685
ClinVar: 8685
TCGA: ENSG00000019169
COSMIC: MARCO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000019169ENST00000327097Q9UEW3
ENSG00000019169ENST00000327097Q4ZG40
ENSG00000019169ENST00000412481C9JKT8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
162371012005MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.53
208109882010The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
118207862002Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO.21
128472632003Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.21
120973272002Characterization of recombinant soluble macrophage scavenger receptor MARCO.19
212998462011The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis.16
236173072013Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.16
194036252009Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors.14

Citation

Dessen P

MARCO (macrophage receptor with collagenous structure)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57064/marco