MARK2 (microtubule affinity regulating kinase 2)

2003-06-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
EMK-1,EMK1,PAR-1,Par-1b,Par1b
FUSION GENES

Other Information

Locus ID:

NCBI: 2011
MIM: 600526
HGNC: 3332
Ensembl: ENSG00000072518

Variants:

dbSNP: 2011
ClinVar: 2011
TCGA: ENSG00000072518
COSMIC: MARK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072518ENST00000350490Q7KZI7
ENSG00000072518ENST00000361128Q7KZI7
ENSG00000072518ENST00000361128A0A140VJP1
ENSG00000072518ENST00000377810E7ETY4
ENSG00000072518ENST00000402010Q7KZI7
ENSG00000072518ENST00000408948Q7KZI7
ENSG00000072518ENST00000408948A0A024R5B2
ENSG00000072518ENST00000425897E7ETY4
ENSG00000072518ENST00000502399E9PC69
ENSG00000072518ENST00000508192Q7KZI7
ENSG00000072518ENST00000509502Q7KZI7
ENSG00000072518ENST00000512060A0A1B0GXH6
ENSG00000072518ENST00000513765Q7KZI7
ENSG00000072518ENST00000540169F5H6N2
ENSG00000072518ENST00000543220F5H4F6
ENSG00000072518ENST00000543674F5H4J8

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172345892007Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1.46
154922572004Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.40
180052422008Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity.35
190111112008Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association.29
242514162013Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.27
220727112011Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization.25
222383442012Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.25
164727372006Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.24
169806132006New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.24
199454242010The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.23

Citation

Dessen P

MARK2 (microtubule affinity regulating kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41300/mark2