MAT1A (methionine adenosyltransferase 1A)

2012-03-01 Affiliation

Identity

HGNC

MAT1A

LOCATION

10q22.3

LOCUSID

4143

ALIAS

MAT,MATA1,SAMS,SAMS1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4143
MIM: 610550
HGNC: 6903
Ensembl: ENSG00000151224

Variants:

dbSNP: 4143
ClinVar: 4143
TCGA: ENSG00000151224
COSMIC: MAT1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151224	ENST00000372213	Q00266
ENSG00000151224	ENST00000455001	B1ANE6

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cysteine and methionine metabolism	KEGG	ko00270
Cysteine and methionine metabolism	KEGG	hsa00270
Metabolic pathways	KEGG	hsa01100
Methionine degradation	KEGG	hsa_M00035
Methionine salvage pathway	KEGG	hsa_M00034
Methionine salvage pathway	KEGG	M00034
Methionine degradation	KEGG	M00035
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Sulfur amino acid metabolism	REACTOME	R-HSA-1614635
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Methylation	REACTOME	R-HSA-156581
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2Se	REACTOME	R-HSA-2408508

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
23241961	2013	MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.	51
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
19161160	2009	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	30
22318685	2012	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	26
19048631	2009	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	20
23425511	2013	Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.	20
20634891	2010	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	18
15935930	2005	Spectrum of hypermethioninemia in neonatal screening.	13

Citation

Dessen P

MAT1A (methionine adenosyltransferase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52635/mat1a