MATK (megakaryocyte-associated tyrosine kinase)

2003-02-01 Affiliation

Identity

HGNC

MATK

LOCATION

19p13.3

LOCUSID

4145

ALIAS

CHK,CTK,HHYLTK,HYL,HYLTK,Lsk

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4145
MIM: 600038
HGNC: 6906
Ensembl: ENSG00000007264

Variants:

dbSNP: 4145
ClinVar: 4145
TCGA: ENSG00000007264
COSMIC: MATK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000007264	ENST00000310132	P42679
ENSG00000007264	ENST00000310132	F1T0G6
ENSG00000007264	ENST00000395040	P42679
ENSG00000007264	ENST00000395045	P42679
ENSG00000007264	ENST00000585778	K7EQY5
ENSG00000007264	ENST00000587180	K7ERY4
ENSG00000007264	ENST00000588983	K7EKS5
ENSG00000007264	ENST00000590028	K7ENL8
ENSG00000007264	ENST00000590493	K7ES68
ENSG00000007264	ENST00000590849	K7EQV3
ENSG00000007264	ENST00000590980	K7EPP2
ENSG00000007264	ENST00000591059	K7EKC4
ENSG00000007264	ENST00000619596	P42679

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Signal Transduction	REACTOME	R-HSA-162582
Signaling by ERBB2	REACTOME	R-HSA-1227986
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15748901	2005	Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.	10
21799000	2011	IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.	10
16707123	2006	Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.	9
16574955	2006	Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice.	8
17934522	2008	Decreased CHK protein levels are associated with Src activation in colon cancer cells.	7
15890649	2005	Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.	4
12122014	2002	Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.	3
12782282	2003	Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.	3
15329911	2004	Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors.	3
12429987	2002	Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.	2

Citation

Dessen P

MATK (megakaryocyte-associated tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41305/matk