Identity
HGNC
LOCATION
20p13
LOCUSID
ALIAS
CARDIF,IPS-1,IPS1,VISA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57506
MIM: 609676
HGNC: 29233
Ensembl: ENSG00000088888
Variants:
dbSNP: 57506
ClinVar: 57506
TCGA: ENSG00000088888
COSMIC: MAVS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000088888 | ENST00000416600 | Q7Z434 |
| ENSG00000088888 | ENST00000428216 | Q7Z434 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134994272 | DDX58 | Gene | Pathway | associated | 26111151 | ||
| PA29917 | IRF3 | Gene | Pathway | associated | 26111151 | ||
| PA29921 | IRF7 | Gene | Pathway | associated | 26111151 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38673764 | 2024 | Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus. | 0 |
| 38673764 | 2024 | Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus. | 0 |
| 36309611 | 2023 | Retinoic acid-inducible gene 1 (RIG-1) and IFN-β promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19). | 1 |
| 36788451 | 2023 | Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response. | 1 |
| 37009655 | 2023 | CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS. | 13 |
| 37537212 | 2023 | MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation. | 3 |
| 38140545 | 2023 | The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. | 2 |
| 36309611 | 2023 | Retinoic acid-inducible gene 1 (RIG-1) and IFN-β promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19). | 1 |
| 36788451 | 2023 | Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response. | 1 |
| 37009655 | 2023 | CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS. | 13 |
| 37537212 | 2023 | MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation. | 3 |
| 38140545 | 2023 | The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. | 2 |
| 34435375 | 2022 | A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis. | 13 |
| 35733260 | 2022 | Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. | 12 |
| 35850307 | 2022 | RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS. | 24 |
Citation
Dessen P
MAVS (mitochondrial antiviral signaling protein)
Atlas Genet Cytogenet Oncol Haematol. 2009-04-01
Online version: http://atlasgeneticsoncology.org/gene/50844/mavs
