MAVS (mitochondrial antiviral signaling protein)

2009-04-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
CARDIF,IPS-1,IPS1,VISA
FUSION GENES

Other Information

Locus ID:

NCBI: 57506
MIM: 609676
HGNC: 29233
Ensembl: ENSG00000088888

Variants:

dbSNP: 57506
ClinVar: 57506
TCGA: ENSG00000088888
COSMIC: MAVS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088888ENST00000416600Q7Z434
ENSG00000088888ENST00000428216Q7Z434

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Hepatitis BKEGGhsa05161
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134994272DDX58GenePathwayassociated26111151
PA29917IRF3GenePathwayassociated26111151
PA29921IRF7GenePathwayassociated26111151

References

Pubmed IDYearTitleCitations
161257632005Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.1174
161778062005Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.942
161538682005VISA is an adapter protein required for virus-triggered IFN-beta signaling.716
217822312011MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.416
256368002015Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.308
197011892009Activation of innate immune antiviral responses by Nod2.279
165855242006Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.194
235823252013The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.182
168584092006Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.153
198815092009PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.122

Citation

Dessen P

MAVS (mitochondrial antiviral signaling protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50844/mavs