MBOAT4 (membrane bound O-acyltransferase domain containing 4)

2013-11-01  

Identity

HGNC
LOCATION
8p12
LOCUSID
ALIAS
FKSG89,GOAT,OACT4

Other Information

Locus ID:

NCBI: 619373
MIM: 611940
HGNC: 32311
Ensembl: ENSG00000177669

Variants:

dbSNP: 619373
ClinVar: 619373
TCGA: ENSG00000177669
COSMIC: MBOAT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177669ENST00000320542Q96T53

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085

References

Pubmed IDYearTitleCitations
241945102014Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.20
228693222012The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes.17
196286762009Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.13
219301732011Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes.5
274892232016Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid.1
184432872008Ghrelin octanoylation mediated by an orphan lipid transferase.0
194798312009Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes.0
210358232011Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa.0
210358232011Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa.0
211505882011The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism.0

Citation

Dessen P

MBOAT4 (membrane bound O-acyltransferase domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53584/mboat4