MCHR2 (melanin concentrating hormone receptor 2)

2016-10-01  

Identity

HGNC
LOCATION
6q16.2
LOCUSID
ALIAS
GPR145,GPRv17,MCH-2R,MCH-R2,MCH2,MCH2R,MCHR-2,SLT
FUSION GENES

Other Information

Locus ID:

NCBI: 84539
MIM: 606111
HGNC: 20867
Ensembl: ENSG00000152034

Variants:

dbSNP: 84539
ClinVar: 84539
TCGA: ENSG00000152034
COSMIC: MCHR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152034ENST00000281806Q969V1
ENSG00000152034ENST00000369212Q969V1

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
195020102009Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.14
159419242005Mutation analysis of the MCHR1 gene in human obesity.8
176989132007Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.7
176989132007Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.7
152298782004Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.5
264612622015Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.4
196838622009Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.2
199273062010A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.2
221233242012Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.2
273069222017Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2.2

Citation

Dessen P

MCHR2 (melanin concentrating hormone receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56492/mchr2