MCM4 (minichromosome maintenance complex component 4)

2003-05-01 Affiliation

Identity

HGNC

MCM4

LOCATION

8q11.21

LOCUSID

4173

ALIAS

CDC21,CDC54,IMD54,NKCD,NKGCD,P1-CDC21,hCdc21

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4173
MIM: 602638
HGNC: 6947
Ensembl: ENSG00000104738

Variants:

dbSNP: 4173
ClinVar: 4173
TCGA: ENSG00000104738
COSMIC: MCM4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104738	ENST00000262105	P33991
ENSG00000104738	ENST00000518221	E5RFR3
ENSG00000104738	ENST00000518382	E5RHP5
ENSG00000104738	ENST00000520637	E5RG31
ENSG00000104738	ENST00000524086	E5RG53
ENSG00000104738	ENST00000647877	A0A3B3ISC1
ENSG00000104738	ENST00000648407	A0A3B3ITP6
ENSG00000104738	ENST00000648519	A0A3B3IS88
ENSG00000104738	ENST00000648554	A0A3B3IRR8
ENSG00000104738	ENST00000649838	A0A3B3IT92
ENSG00000104738	ENST00000649919	A0A3B3IU45
ENSG00000104738	ENST00000649973	P33991
ENSG00000104738	ENST00000650216	A0A3B3IS57

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
DNA replication	KEGG	ko03030
Cell cycle	KEGG	ko04110
DNA replication	KEGG	hsa03030
Cell cycle	KEGG	hsa04110
MCM complex	KEGG	hsa_M00285
MCM complex	KEGG	M00285
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G2/M Checkpoints	REACTOME	R-HSA-69481
Activation of ATR in response to replication stress	REACTOME	R-HSA-176187
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1/S Transition	REACTOME	R-HSA-69206
Activation of the pre-replicative complex	REACTOME	R-HSA-68962
S Phase	REACTOME	R-HSA-69242
Synthesis of DNA	REACTOME	R-HSA-69239
Switching of origins to a post-replicative state	REACTOME	R-HSA-69052
Orc1 removal from chromatin	REACTOME	R-HSA-68949
DNA strand elongation	REACTOME	R-HSA-69190
Unwinding of DNA	REACTOME	R-HSA-176974
Regulation of DNA replication	REACTOME	R-HSA-69304
Removal of licensing factors from origins	REACTOME	R-HSA-69300
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
Assembly of the pre-replicative complex	REACTOME	R-HSA-68867
DNA Replication	REACTOME	R-HSA-69306

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17046832	2006	Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.	95
22354167	2012	Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.	84
22354170	2012	MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.	75
12714602	2003	Identification of MCM4 as a target of the DNA replication block checkpoint system.	40
17005684	2006	Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.	38
20398247	2010	Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma.	30
19074885	2008	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	25
25733866	2015	Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.	25
20884074	2011	Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.	23
16519687	2006	Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.	21

Citation

Dessen P

MCM4 (minichromosome maintenance complex component 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41320/mcm4