MCM9 (minichromosome maintenance 9 homologous recombination repair factor)

2012-09-01  

Identity

HGNC
LOCATION
6q22.31
LOCUSID
ALIAS
C6orf61,MCMDC1,ODG4,dJ329L24.1,dJ329L24.3
FUSION GENES

Other Information

Locus ID:

NCBI: 254394
MIM: 610098
HGNC: 21484
Ensembl: ENSG00000111877

Variants:

dbSNP: 254394
ClinVar: 254394
TCGA: ENSG00000111877
COSMIC: MCM9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111877ENST00000316068Q9NXL9
ENSG00000111877ENST00000316068A0A0S2Z662
ENSG00000111877ENST00000316316Q9NXL9
ENSG00000111877ENST00000425154D6RHY8
ENSG00000111877ENST00000458674H0Y6M9
ENSG00000111877ENST00000505446D6RE85
ENSG00000111877ENST00000619706Q9NXL9

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234018552013The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.33
186575022008MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.27
278020942017MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency.15
284874072017Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.12
306488202019Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.4
304064452019Gene variants identified by whole-exome sequencing in 33 French women with premature ovarian insufficiency.1
158508102005Identification of a novel cell-cycle-induced MCM family protein MCM9.0
162268532005Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family.0
234032372013Identification, quantification, and evolutionary analysis of a novel isoform of MCM9.0
254800362014MCM9 mutations are associated with ovarian failure, short stature, and chromosomal instability.0

Citation

Dessen P

MCM9 (minichromosome maintenance 9 homologous recombination repair factor)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52895/mcm9