MCMBP (minichromosome maintenance complex binding protein)

2014-08-01  

Identity

HGNC
LOCATION
10q26.11
LOCUSID
ALIAS
C10orf119,MCM-BP
FUSION GENES

Other Information

Locus ID:

NCBI: 79892
MIM: 610909
HGNC: 25782
Ensembl: ENSG00000197771

Variants:

dbSNP: 79892
ClinVar: 79892
TCGA: ENSG00000197771
COSMIC: MCMBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197771ENST00000360003Q9BTE3
ENSG00000197771ENST00000369077Q9BTE3
ENSG00000197771ENST00000369077A0A0S2Z5P5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
200909392010The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair.24
211964932011MCM-BP regulates unloading of the MCM2-7 helicase in late S phase.24
172967312007Identification and characterization of a novel component of the human minichromosome maintenance complex.23
241909672014A role for USP7 in DNA replication.21
222502012012The MCM-associated protein MCM-BP is important for human nuclear morphology.13
225400122012Interactions of the human MCM-BP protein with MCM complex components and Dbf4.7
252462712014Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability.3

Citation

Dessen P

MCMBP (minichromosome maintenance complex binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54446/mcmbp