MCU (mitochondrial calcium uniporter)

2013-08-01  

Identity

HGNC
MCU
LOCATION
10q22.1
LOCUSID
90550
ALIAS
C10orf42,CCDC109A,HsMCU
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90550
MIM: 614197
HGNC: 23526
Ensembl: ENSG00000156026

Variants:

dbSNP: 90550
ClinVar: 90550
TCGA: ENSG00000156026
COSMIC: MCU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156026ENST00000357157Q8NE86
ENSG00000156026ENST00000373053Q8NE86
ENSG00000156026ENST00000536019Q8NE86
ENSG00000156026ENST00000603649S4R3F5
ENSG00000156026ENST00000604152S4R468
ENSG00000156026ENST00000604372S4R3W8
ENSG00000156026ENST00000604679S4R319
ENSG00000156026ENST00000605597S4R332

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186140152008A mitochondrial protein compendium elucidates complex I disease biology.709
216858882011A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.596
216858862011Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.582
243662632014The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications.73
237553632013MCU encodes the pore conducting mitochondrial calcium currents.65
282625042017Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.57
271385682016The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.53
270999882016Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.51
234007772013The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.42
229043192012Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells.41

Citation

Dessen P

MCU (mitochondrial calcium uniporter)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53485/mcu