MCUB (mitochondrial calcium uniporter dominant negative subunit beta)

2018-07-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
CCDC109B

Other Information

Locus ID:

NCBI: 55013
HGNC: 26076
Ensembl: ENSG00000005059

Variants:

dbSNP: 55013
ClinVar: 55013
TCGA: ENSG00000005059
COSMIC: MCUB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005059ENST00000394650Q9NWR8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
242318072013EMRE is an essential component of the mitochondrial calcium uniporter complex.210
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
315334522019MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.7
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
287541212017Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas.4

Citation

Dessen P

MCUB (mitochondrial calcium uniporter dominant negative subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57554/mcub