MCUR1 (mitochondrial calcium uniporter regulator 1)

2019-08-01  

Identity

HGNC
MCUR1
LOCATION
6p23
LOCUSID
63933
ALIAS
C6orf79,CCDC90A,FMP32

Other Information

Locus ID:

NCBI: 63933
MIM: 616952
HGNC: 21097
Ensembl: ENSG00000050393

Variants:

dbSNP: 63933
ClinVar: 63933
TCGA: ENSG00000050393
COSMIC: MCUR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050393ENST00000379170Q96AQ8
ENSG00000050393ENST00000379170A0A384NPW7
ENSG00000050393ENST00000488770Q96AQ8
ENSG00000050393ENST00000607303U3KQP8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
255652092015CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.38
269765642016Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.25
270016092016Analysis of the structure and function of EMRE in a yeast expression system.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
309099292019MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma.9
289388442018MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.8

Citation

Dessen P

MCUR1 (mitochondrial calcium uniporter regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58157/mcur1