MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2)

2017-08-01  

Identity

HGNC
LOCATION
14q21.3
LOCUSID
ALIAS
MAMDC1,c14_5286
FUSION GENES

Other Information

Locus ID:

NCBI: 161357
MIM: 611128
HGNC: 19835
Ensembl: ENSG00000139915

Variants:

dbSNP: 161357
ClinVar: 161357
TCGA: ENSG00000139915
COSMIC: MDGA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139915ENST00000357362Q7Z553
ENSG00000139915ENST00000399232Q7Z553
ENSG00000139915ENST00000426342Q7Z553
ENSG00000139915ENST00000482848E9PMG9
ENSG00000139915ENST00000486952G3V5U0
ENSG00000139915ENST00000554762H0YJ52
ENSG00000139915ENST00000557238G3V5Z1

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164752812milnacipranChemicalClinicalAnnotationassociatedPD22445761
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD22445761
PA449690fluvoxamineChemicalClinicalAnnotationassociatedPD22445761
PA450801paroxetineChemicalClinicalAnnotationassociatedPD22445761

References

Pubmed IDYearTitleCitations
195571952009Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.175
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
187625922008Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.42
187625922008Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.42
262066652016MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
215429082011Rostral growth of commissural axons requires the cell adhesion molecule MDGA2.9
194401642009Follow-up association study of novel neuroticism gene MAMDC1.4
199975612009Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).2

Citation

Dessen P

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57033/mdga2