Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MDK (midkine)

Identity

Alias (NCBI)ARAP
MK
NEGF2
HGNC (Hugo) MDK
HGNC Alias symbMK
FLJ27379
HGNC Previous nameNEGF2
HGNC Previous nameneurite growth-promoting factor 2
LocusID (NCBI) 4192
Atlas_Id 41328
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46381669 and ends at 46383825 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MDK (11p11.2) / ERBB2 (17q12)MDK (11p11.2) / RABGAP1 (9q33.2)MDK (11p11.2) / TMED2 (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Soft Tissues: Desmoid-type fibromatosis
t(11;17)(p11;q12) MDK/ERBB2

External links

Nomenclature
HGNC (Hugo)MDK   6972
Cards
Entrez_Gene (NCBI)MDK  4192  midkine
AliasesARAP; MK; NEGF2
GeneCards (Weizmann)MDK
Ensembl hg19 (Hinxton)ENSG00000110492 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110492 [Gene_View]  ENSG00000110492 [Sequence]  chr11:46381669-46383825 [Contig_View]  MDK [Vega]
ICGC DataPortalENSG00000110492
TCGA cBioPortalMDK
AceView (NCBI)MDK
Genatlas (Paris)MDK
WikiGenes4192
SOURCE (Princeton)MDK
Genetics Home Reference (NIH)MDK
Genomic and cartography
GoldenPath hg38 (UCSC)MDK  -     chr11:46381669-46383825 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MDK  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathMDK - 11p11.2 [CytoView hg19]  MDK - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000110492
genome Data Viewer NCBIMDK [Mapview hg19]  
OMIM162096   
Gene and transcription
Genbank (Entrez)AI494596 AK130889 AK308210 AK309963 BC011704
RefSeq transcript (Entrez)NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552 NM_002391
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MDK
Alternative Splicing GalleryENSG00000110492
Gene ExpressionMDK [ NCBI-GEO ]   MDK [ EBI - ARRAY_EXPRESS ]   MDK [ SEEK ]   MDK [ MEM ]
Gene Expression Viewer (FireBrowse)MDK [ Firebrowse - Broad ]
GenevisibleExpression of MDK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4192
GTEX Portal (Tissue expression)MDK
Human Protein AtlasENSG00000110492-MDK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21741   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21741  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21741
Splice isoforms : SwissVarP21741
PhosPhoSitePlusP21741
Domaine pattern : Prosite (Expaxy)PTN_MK_1 (PS00619)    PTN_MK_2 (PS00620)   
Domains : Interpro (EBI)Midkine_heparin-bd_GF    PTN/MK_C_dom    PTN/MK_C_dom_sf    PTN/MK_diS_sf    PTN/MK_N_dom    PTN/MK_N_dom_sf    PTN_MK_heparin-bd_GF_CS   
Domain families : Pfam (Sanger)PTN_MK_C (PF01091)    PTN_MK_N (PF05196)   
Domain families : Pfam (NCBI)pfam01091    pfam05196   
Domain families : Smart (EMBL)PTN (SM00193)  
Conserved Domain (NCBI)MDK
DMDM Disease mutations4192
Blocks (Seattle)MDK
PDB (RSDB)1MKC    1MKN   
PDB Europe1MKC    1MKN   
PDB (PDBSum)1MKC    1MKN   
PDB (IMB)1MKC    1MKN   
Structural Biology KnowledgeBase1MKC    1MKN   
SCOP (Structural Classification of Proteins)1MKC    1MKN   
CATH (Classification of proteins structures)1MKC    1MKN   
SuperfamilyP21741
Human Protein Atlas [tissue]ENSG00000110492-MDK [tissue]
Peptide AtlasP21741
HPRD01200
IPIIPI00010333   IPI00942093   IPI00719019   IPI00719099   IPI01018295   IPI00979574   IPI00719163   
Protein Interaction databases
DIP (DOE-UCLA)P21741
IntAct (EBI)P21741
FunCoupENSG00000110492
BioGRIDMDK
STRING (EMBL)MDK
ZODIACMDK
Ontologies - Pathways
QuickGOP21741
Ontology : AmiGObehavioral fear response  leukocyte chemotaxis involved in inflammatory response  leukocyte chemotaxis involved in inflammatory response  T cell activation involved in immune response  positive regulation of leukocyte chemotaxis  protein binding  extracellular region  cytoplasm  cytoskeleton organization  negative regulation of cell adhesion  signal transduction  Notch signaling pathway  nervous system development  short-term memory  growth factor activity  growth factor activity  heparin binding  response to wounding  negative regulation of cardiac muscle cell apoptotic process  negative regulation of cardiac muscle cell apoptotic process  positive regulation of epithelial to mesenchymal transition  positive regulation of macrophage chemotaxis  positive regulation of macrophage chemotaxis  positive regulation of keratinocyte proliferation  positive regulation of neuron projection development  positive regulation of neuron projection development  response to auditory stimulus  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  negative regulation of ossification  adrenal gland development  positive regulation of cell migration  defecation  regulation of chondrocyte differentiation  chondroitin sulfate binding  tissue regeneration  response to drug  cell projection  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of T cell differentiation  negative regulation of regulatory T cell differentiation  positive regulation of cell adhesion  positive regulation of transcription, DNA-templated  regulation of bone remodeling  oogenesis  positive regulation of oligodendrocyte differentiation  positive regulation of inflammatory response  regulation of behavior  response to glucocorticoid  positive regulation of cell division  positive regulation of cartilage development  collagen-containing extracellular matrix  positive regulation of smooth muscle cell chemotaxis  positive regulation of neutrophil chemotaxis  negative regulation of canonical Wnt signaling pathway  negative regulation of inflammatory response to wounding  positive regulation of inflammatory response to wounding  glial cell projection elongation  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of leukocyte cell-cell adhesion  negative regulation of epithelial cell apoptotic process  heparan sulfate binding  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation blood vessel branching  positive regulation of vascular endothelial cell proliferation  positive regulation of artery morphogenesis  positive regulation of neural precursor cell proliferation  regulation of actin cytoskeleton reorganization  positive regulation of hepatocyte proliferation  positive regulation of neutrophil extravasation  positive regulation of interleukin-12 secretion  positive regulation of neuron migration  
Ontology : EGO-EBIbehavioral fear response  leukocyte chemotaxis involved in inflammatory response  leukocyte chemotaxis involved in inflammatory response  T cell activation involved in immune response  positive regulation of leukocyte chemotaxis  protein binding  extracellular region  cytoplasm  cytoskeleton organization  negative regulation of cell adhesion  signal transduction  Notch signaling pathway  nervous system development  short-term memory  growth factor activity  growth factor activity  heparin binding  response to wounding  negative regulation of cardiac muscle cell apoptotic process  negative regulation of cardiac muscle cell apoptotic process  positive regulation of epithelial to mesenchymal transition  positive regulation of macrophage chemotaxis  positive regulation of macrophage chemotaxis  positive regulation of keratinocyte proliferation  positive regulation of neuron projection development  positive regulation of neuron projection development  response to auditory stimulus  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  negative regulation of ossification  adrenal gland development  positive regulation of cell migration  defecation  regulation of chondrocyte differentiation  chondroitin sulfate binding  tissue regeneration  response to drug  cell projection  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of T cell differentiation  negative regulation of regulatory T cell differentiation  positive regulation of cell adhesion  positive regulation of transcription, DNA-templated  regulation of bone remodeling  oogenesis  positive regulation of oligodendrocyte differentiation  positive regulation of inflammatory response  regulation of behavior  response to glucocorticoid  positive regulation of cell division  positive regulation of cartilage development  collagen-containing extracellular matrix  positive regulation of smooth muscle cell chemotaxis  positive regulation of neutrophil chemotaxis  negative regulation of canonical Wnt signaling pathway  negative regulation of inflammatory response to wounding  positive regulation of inflammatory response to wounding  glial cell projection elongation  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of leukocyte cell-cell adhesion  negative regulation of epithelial cell apoptotic process  heparan sulfate binding  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation blood vessel branching  positive regulation of vascular endothelial cell proliferation  positive regulation of artery morphogenesis  positive regulation of neural precursor cell proliferation  regulation of actin cytoskeleton reorganization  positive regulation of hepatocyte proliferation  positive regulation of neutrophil extravasation  positive regulation of interleukin-12 secretion  positive regulation of neuron migration  
NDEx NetworkMDK
Atlas of Cancer Signalling NetworkMDK
Wikipedia pathwaysMDK
Orthology - Evolution
OrthoDB4192
GeneTree (enSembl)ENSG00000110492
Phylogenetic Trees/Animal Genes : TreeFamMDK
HOGENOMP21741
Homologs : HomoloGeneMDK
Homology/Alignments : Family Browser (UCSC)MDK
Gene fusions - Rearrangements
Fusion : QuiverMDK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMDK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MDK
dbVarMDK
ClinVarMDK
1000_GenomesMDK 
Exome Variant ServerMDK
GNOMAD BrowserENSG00000110492
Varsome BrowserMDK
Genetic variants : HAPMAP4192
Genomic Variants (DGV)MDK [DGVbeta]
DECIPHERMDK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMDK 
Mutations
ICGC Data PortalMDK 
TCGA Data PortalMDK 
Broad Tumor PortalMDK
OASIS PortalMDK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMDK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMDK
Mutations and Diseases : HGMDMDK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MDK
DgiDB (Drug Gene Interaction Database)MDK
DoCM (Curated mutations)MDK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MDK (select a term)
intoGenMDK
Cancer3DMDK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162096   
Orphanet
DisGeNETMDK
MedgenMDK
Genetic Testing Registry MDK
NextProtP21741 [Medical]
TSGene4192
GENETestsMDK
Target ValidationMDK
Huge Navigator MDK [HugePedia]
snp3D : Map Gene to Disease4192
BioCentury BCIQMDK
ClinGenMDK
Clinical trials, drugs, therapy
Protein Interactions : CTD4192
Pharm GKB GenePA30717
Clinical trialMDK
Miscellaneous
canSAR (ICR)MDK (select the gene name)
HarmonizomeMDK
DataMed IndexMDK
Probes
Litterature
PubMed176 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMDK
EVEXMDK
GoPubMedMDK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:22:35 CEST 2020
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