ME2 (malic enzyme 2)

2009-06-01  

Identity

HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
ODS1
FUSION GENES

Other Information

Locus ID:

NCBI: 4200
MIM: 154270
HGNC: 6984
Ensembl: ENSG00000082212

Variants:

dbSNP: 4200
ClinVar: 4200
TCGA: ENSG00000082212
COSMIC: ME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082212ENST00000321341P23368
ENSG00000082212ENST00000382927P23368
ENSG00000082212ENST00000585680A0A1W2PPY2
ENSG00000082212ENST00000638410A0A1W2PQT3
ENSG00000082212ENST00000638937A0A1W2PQY8
ENSG00000082212ENST00000639115A0A1W2PRY9
ENSG00000082212ENST00000639255A0A1W2PR68
ENSG00000082212ENST00000639398A0A1W2PRH1
ENSG00000082212ENST00000639612A0A1W2PRS2
ENSG00000082212ENST00000639665A0A1W2PQ37
ENSG00000082212ENST00000639688A0A1W2PRY9
ENSG00000082212ENST00000639850A0A1W2PPH1
ENSG00000082212ENST00000640530A0A1W2PQH4
ENSG00000082212ENST00000640965A0A1W2PQH3
ENSG00000082212ENST00000640967A0A1W2PQF8

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
Pyruvate metabolismKEGGhsa00620
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233344212013Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.143
280994192017Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.55
249570982014Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.24
190663932009Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.22
155320132005Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
208240652010Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.16
237564802013The quest for juvenile myoclonic epilepsy genes.14
161713882005Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.9
252028252015Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.9

Citation

Dessen P

ME2 (malic enzyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50969/me2