MED15 (mediator complex subunit 15)

2007-02-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
ARC105,CAG7A,CTG7A,PCQAP,TIG-1,TIG1,TNRC7
FUSION GENES

Other Information

Locus ID:

NCBI: 51586
MIM: 607372
HGNC: 14248
Ensembl: ENSG00000099917

Variants:

dbSNP: 51586
ClinVar: 51586
TCGA: ENSG00000099917
COSMIC: MED15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099917ENST00000263205Q96RN5
ENSG00000099917ENST00000292733Q96RN5
ENSG00000099917ENST00000382974Q96RN5
ENSG00000099917ENST00000406969G3V1P5
ENSG00000099917ENST00000414658C9J1I1
ENSG00000099917ENST00000420849F8WCS1
ENSG00000099917ENST00000423862H7C308
ENSG00000099917ENST00000424287C9JCQ3
ENSG00000099917ENST00000428629C9JWK5
ENSG00000099917ENST00000432052C9JLN7
ENSG00000099917ENST00000433831F2Z2B7
ENSG00000099917ENST00000438962C9JEM1
ENSG00000099917ENST00000441501F8WEJ4
ENSG00000099917ENST00000444094F8WDM6
ENSG00000099917ENST00000445189C9JGN2
ENSG00000099917ENST00000445987C9JZV5
ENSG00000099917ENST00000451058C9JM58
ENSG00000099917ENST00000457322C9JJ12

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167995632006An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.161
102352671999Composite co-activator ARC mediates chromatin-directed transcriptional activation.130
146914532004Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene.26
169046692006TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system.18
154553912005Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma.16
229160342012Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.14
243748382014MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer.7
279747042017MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.7
124976102003Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia.6
200259402010Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex.5

Citation

Dessen P

MED15 (mediator complex subunit 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43823/med15