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MED20 (mediator complex subunit 20)

Identity

Alias_namesTRFP
Trf (TATA binding protein-related factor)-proximal homolog (Drosophila)
Alias_symbol (synonym)DKFZp586D2223
PRO0213
Other aliasSRB2
HGNC (Hugo) MED20
LocusID (NCBI) 9477
Atlas_Id 68876
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41905353 and ends at 41921147 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKR1A1 (1p34.1) / MED20 (6p21.1)MED20 (6p21.1) / RNF182 (6p23)MED20 (6p21.1) / TLL2 (10q24.1)
MED20 (6p21.1) / USP49 (6p21.1)USP49 (6p21.1) / MED20 (6p21.1)MED20 RNF182
MED20 TLL2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MED20   16840
Cards
Entrez_Gene (NCBI)MED20  9477  mediator complex subunit 20
AliasesPRO0213; SRB2; TRFP
GeneCards (Weizmann)MED20
Ensembl hg19 (Hinxton)ENSG00000124641 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124641 [Gene_View]  ENSG00000124641 [Sequence]  chr6:41905353-41921147 [Contig_View]  MED20 [Vega]
ICGC DataPortalENSG00000124641
TCGA cBioPortalMED20
AceView (NCBI)MED20
Genatlas (Paris)MED20
WikiGenes9477
SOURCE (Princeton)MED20
Genetics Home Reference (NIH)MED20
Genomic and cartography
GoldenPath hg38 (UCSC)MED20  -     chr6:41905353-41921147 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED20  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathMED20 - 6p21.1 [CytoView hg19]  MED20 - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000124641
Mapping of homologs : NCBIMED20 [Mapview hg19]  MED20 [Mapview hg38]
OMIM612915   
Gene and transcription
Genbank (Entrez)AF097725 AF116602 AJ420544 AK023092 AK097385
RefSeq transcript (Entrez)NM_001305455 NM_001305456 NM_001305457 NM_004275
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED20
Cluster EST : UnigeneHs.278434 [ NCBI ]
CGAP (NCI)Hs.278434
Alternative Splicing GalleryENSG00000124641
Gene ExpressionMED20 [ NCBI-GEO ]   MED20 [ EBI - ARRAY_EXPRESS ]   MED20 [ SEEK ]   MED20 [ MEM ]
Gene Expression Viewer (FireBrowse)MED20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9477
GTEX Portal (Tissue expression)MED20
Human Protein AtlasENSG00000124641-MED20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H944   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H944  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H944
Splice isoforms : SwissVarQ9H944
PhosPhoSitePlusQ9H944
Domains : Interpro (EBI)Mediator_Med20   
Domain families : Pfam (Sanger)Med20 (PF08612)   
Domain families : Pfam (NCBI)pfam08612   
Conserved Domain (NCBI)MED20
DMDM Disease mutations9477
Blocks (Seattle)MED20
SuperfamilyQ9H944
Human Protein Atlas [tissue]ENSG00000124641-MED20 [tissue]
Peptide AtlasQ9H944
HPRD15638
IPIIPI00174852   IPI00383380   IPI00853365   IPI00916139   IPI00917086   IPI00916936   
Protein Interaction databases
DIP (DOE-UCLA)Q9H944
IntAct (EBI)Q9H944
FunCoupENSG00000124641
BioGRIDMED20
STRING (EMBL)MED20
ZODIACMED20
Ontologies - Pathways
QuickGOQ9H944
Ontology : AmiGOubiquitin ligase complex  transcription coactivator activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  mediator complex  ubiquitin protein ligase activity  positive regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIubiquitin ligase complex  transcription coactivator activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  mediator complex  ubiquitin protein ligase activity  positive regulation of nucleic acid-templated transcription  
NDEx NetworkMED20
Atlas of Cancer Signalling NetworkMED20
Wikipedia pathwaysMED20
Orthology - Evolution
OrthoDB9477
GeneTree (enSembl)ENSG00000124641
Phylogenetic Trees/Animal Genes : TreeFamMED20
HOGENOMQ9H944
Homologs : HomoloGeneMED20
Homology/Alignments : Family Browser (UCSC)MED20
Gene fusions - Rearrangements
Fusion PortalMED20 RNF182
Fusion PortalMED20 TLL2
Fusion : QuiverMED20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED20
dbVarMED20
ClinVarMED20
1000_GenomesMED20 
Exome Variant ServerMED20
ExAC (Exome Aggregation Consortium)ENSG00000124641
GNOMAD BrowserENSG00000124641
Varsome BrowserMED20
Genetic variants : HAPMAP9477
Genomic Variants (DGV)MED20 [DGVbeta]
DECIPHERMED20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED20 
Mutations
ICGC Data PortalMED20 
TCGA Data PortalMED20 
Broad Tumor PortalMED20
OASIS PortalMED20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED20  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED20
Mutations and Diseases : HGMDMED20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED20
DgiDB (Drug Gene Interaction Database)MED20
DoCM (Curated mutations)MED20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED20 (select a term)
intoGenMED20
Cancer3DMED20(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612915   
Orphanet
DisGeNETMED20
MedgenMED20
Genetic Testing Registry MED20
NextProtQ9H944 [Medical]
TSGene9477
GENETestsMED20
Target ValidationMED20
Huge Navigator MED20 [HugePedia]
snp3D : Map Gene to Disease9477
BioCentury BCIQMED20
ClinGenMED20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9477
Chemical/Pharm GKB GenePA162395472
Clinical trialMED20
Miscellaneous
canSAR (ICR)MED20 (select the gene name)
DataMed IndexMED20
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED20
EVEXMED20
GoPubMedMED20
iHOPMED20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:51:53 CEST 2019
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