MELTF (melanotransferrin)

2015-03-01  

Identity

HGNC
MELTF
LOCATION
3q29
LOCUSID
4241
ALIAS
CD228,MAP97,MFI2,MTF1,MTf
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4241
MIM: 155750
HGNC: 7037
Ensembl: ENSG00000163975

Variants:

dbSNP: 4241
ClinVar: 4241
TCGA: ENSG00000163975
COSMIC: MELTF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163975ENST00000296350P08582
ENSG00000163975ENST00000296351P08582
ENSG00000163975ENST00000296351Q53XS6
ENSG00000163975ENST00000439320C9JVN1

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
211905622010PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.18
167049912006The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis.13
174499032007Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo.10
174529862007The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.10
252163272014Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.10
127501562003Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration.6
127109452003Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.5
128095502003Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease.5
122305552002The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.4
157160252005Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human.4

Citation

Dessen P

MELTF (melanotransferrin)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55648/meltf