MEOX2 (mesenchyme homeobox 2)

2010-01-01  

Identity

HGNC
MEOX2
LOCATION
7p21.2
LOCUSID
4223
ALIAS
GAX,MOX2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4223
MIM: 600535
HGNC: 7014
Ensembl: ENSG00000106511

Variants:

dbSNP: 4223
ClinVar: 4223
TCGA: ENSG00000106511
COSMIC: MEOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106511ENST00000262041P50222

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179570282008Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5.164
161164302005Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.86
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
128424532003Inhibition of endothelial cell activation by the homeobox gene Gax.19
255615142015Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.18
170747592007The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.16
193403002009A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.12
222060002011Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.12
193832872007Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.11
197606042009Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.9

Citation

Dessen P

MEOX2 (mesenchyme homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51256/meox2