MESD (mesoderm development LRP chaperone)

2017-08-01 Affiliation

HGNC

MESD

LOCATION

15q25.1

LOCUSID

23184

ALIAS

BOCA,MESDC2,OI20

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

dbSNP: 23184
ClinVar: 23184
TCGA: ENSG00000117899
COSMIC: MESD

Not detected

Low

Medium

High

Pubmed ID	Year	Title	Citations
21907199	2011	Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.	18
16989816	2006	Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.	11
21337463	2011	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	8
21397183	2011	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	7
23469146	2013	The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.	7
15917269	2005	Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).	2
19746449	2009	A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).	2
31564437	2019	Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta.	1

Dessen P

MESD (mesoderm development LRP chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01