MESP1 (mesoderm posterior bHLH transcription factor 1)

2017-04-01  

Identity

HGNC
MESP1
LOCATION
15q26.1
LOCUSID
55897
ALIAS
bHLHc5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55897
MIM: 608689
HGNC: 29658
Ensembl: ENSG00000166823

Variants:

dbSNP: 55897
ClinVar: 55897
TCGA: ENSG00000166823
COSMIC: MESP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166823ENST00000300057Q9BRJ9

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
182970602008MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling.91
228262362012Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.79
251873012015Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.19
266942032016MESP1 Mutations in Patients with Congenital Heart Defects.9
240560642013Mutational analysis of the human MESP1 gene in patients with congenital heart disease reveals a highly variable sequence in exon 1.3
303893442019MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.2
286777472017MESP1 loss‑of‑function mutation contributes to double outlet right ventricle.1
317616212019Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis.0

Citation

Dessen P

MESP1 (mesoderm posterior bHLH transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56735/mesp1