METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit)

2019-08-01  

Identity

HGNC
METTL14
LOCATION
4q26
LOCUSID
57721
ALIAS
hMETTL14

Other Information

Locus ID:

NCBI: 57721
MIM: 616504
HGNC: 29330
Ensembl: ENSG00000145388

Variants:

dbSNP: 57721
ClinVar: 57721
TCGA: ENSG00000145388
COSMIC: METTL14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145388ENST00000388822Q9HCE5
ENSG00000145388ENST00000506780D6RBL4
ENSG00000145388ENST00000508801D6RD73
ENSG00000145388ENST00000626212A0A0D9SF88
ENSG00000145388ENST00000628452A0A0D9SFW0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
243167152014A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.484
272811942016Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.125
292906172018METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.113
276277982016Structural insights into the molecular mechanism of the m(6)A writer complex.81
293481402018Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.34
303061282018Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.29
282479492017NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.14
300066132018Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells.14
312261602019EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.9
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8

Citation

Dessen P

METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58112/mettl14