Identity
HGNC
LOCATION
2q33.3
LOCUSID
ALIAS
FAM119A,HCA557b,HSPA-KMT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 151194
MIM: 615257
HGNC: 30476
Ensembl: ENSG00000144401
Variants:
dbSNP: 151194
ClinVar: 151194
TCGA: ENSG00000144401
COSMIC: METTL21A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Post-translational protein modification | REACTOME | R-HSA-597592 |
| Protein methylation | REACTOME | R-HSA-8876725 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 17548750, 20643483 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 17548750, 20643483 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 17548750, 20643483 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 23349634 | 2013 | A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. | 97 |
| 23921388 | 2013 | Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. | 65 |
| 23349634 | 2013 | A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. | 97 |
| 23921388 | 2013 | Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. | 65 |
Citation
Dessen P
METTL21A (methyltransferase 21A, HSPA lysine)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41173/mettl21a
