METTL21A (methyltransferase 21A, HSPA lysine)

2003-06-01  

Identity

HGNC
LOCATION
2q33.3
LOCUSID
ALIAS
FAM119A,HCA557b,HSPA-KMT
FUSION GENES

Other Information

Locus ID:

NCBI: 151194
MIM: 615257
HGNC: 30476
Ensembl: ENSG00000144401

Variants:

dbSNP: 151194
ClinVar: 151194
TCGA: ENSG00000144401
COSMIC: METTL21A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144401ENST00000272839H7BXH9
ENSG00000144401ENST00000406927Q8WXB1
ENSG00000144401ENST00000411432Q8WXB1
ENSG00000144401ENST00000425132Q8WXB1
ENSG00000144401ENST00000426075Q8WXB1
ENSG00000144401ENST00000432416C9JES0
ENSG00000144401ENST00000442521Q8WXB1
ENSG00000144401ENST00000448007Q8WXB1
ENSG00000144401ENST00000448823C9JSX1
ENSG00000144401ENST00000458426Q8WXB1

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447278DepressionDiseaseClinicalAnnotationassociatedPD17548750, 20643483
PA449015citalopramChemicalClinicalAnnotationassociatedPD17548750, 20643483
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD17548750, 20643483

References

Pubmed IDYearTitleCitations
233496342013A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.71
239213882013Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.47

Citation

Dessen P

METTL21A (methyltransferase 21A, HSPA lysine)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41173/mettl21a