METTL22 (methyltransferase 22, Kin17 lysine)

2014-11-01  

Identity

HGNC
METTL22
LOCATION
16p13.2
LOCUSID
79091
ALIAS
C16orf68

Other Information

Locus ID:

NCBI: 79091
MIM: 615261
HGNC: 28368
Ensembl: ENSG00000067365

Variants:

dbSNP: 79091
ClinVar: 79091
TCGA: ENSG00000067365
COSMIC: METTL22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067365ENST00000163678Q9BUU2
ENSG00000067365ENST00000381920Q9BUU2
ENSG00000067365ENST00000561758H3BTF5
ENSG00000067365ENST00000562151I3L483
ENSG00000067365ENST00000562973I3L3I8
ENSG00000067365ENST00000563958H3BTR2
ENSG00000067365ENST00000564554H3BSA9
ENSG00000067365ENST00000565866H3BTI6
ENSG00000067365ENST00000567295H3BV20
ENSG00000067365ENST00000572956I3L2J5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233496342013A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.71

Citation

Dessen P

METTL22 (methyltransferase 22, Kin17 lysine)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68918/mettl22