Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51320
MIM: 611005
HGNC: 28040
Ensembl: ENSG00000176624
Variants:
dbSNP: 51320
ClinVar: 51320
TCGA: ENSG00000176624
COSMIC: MEX3C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000176624 | ENST00000406189 | Q5U5Q3 |
| ENSG00000176624 | ENST00000592416 | K7ER23 |
| ENSG00000176624 | ENST00000616921 | M9T4I7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712563 | Bisphosphonates | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445187 | Osteonecrosis | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38424632 | 2024 | Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma. | 0 |
| 38424632 | 2024 | Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma. | 0 |
| 37828435 | 2023 | MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib. | 0 |
| 37828435 | 2023 | MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib. | 0 |
| 36112698 | 2022 | MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma. | 6 |
| 36112698 | 2022 | MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma. | 6 |
| 33896797 | 2021 | Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity. | 11 |
| 33896797 | 2021 | Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity. | 11 |
| 32862604 | 2020 | MEX3C promotes osteosarcoma malignant progression through negatively regulating FGF14. | 3 |
| 32862604 | 2020 | MEX3C promotes osteosarcoma malignant progression through negatively regulating FGF14. | 3 |
| 28808060 | 2017 | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity. | 16 |
| 28808060 | 2017 | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity. | 16 |
| 26471122 | 2015 | A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. | 24 |
| 26471122 | 2015 | A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. | 24 |
| 22863774 | 2012 | The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. | 46 |
Citation
Dessen P
MEX3C (mex-3 RNA binding family member C)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47496/mex3c
