MFAP5 (microfibril associated protein 5)

2010-01-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
AAT9,MAGP-2,MAGP2,MFAP-5,MP25

Other Information

Locus ID:

NCBI: 8076
MIM: 601103
HGNC: 29673
Ensembl: ENSG00000197614

Variants:

dbSNP: 8076
ClinVar: 8076
TCGA: ENSG00000197614
COSMIC: MFAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197614ENST00000359478Q13361
ENSG00000197614ENST00000396549Q13361
ENSG00000197614ENST00000433590B3KW70
ENSG00000197614ENST00000535336F5H413
ENSG00000197614ENST00000535411H0YG03
ENSG00000197614ENST00000537009F5H2W4
ENSG00000197614ENST00000540087Q13361
ENSG00000197614ENST00000543369F5GYX4
ENSG00000197614ENST00000543467H0YGS3
ENSG00000197614ENST00000544211F5H7Z2
ENSG00000197614ENST00000544889F5H1C0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199626702009A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.100
164926722006Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.46
252772122014Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.40
254340062014MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections.35
184171562008Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells.25
244963842014Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.17
296811582018Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.14
260540062015MFAP5 is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation.11
295267532018MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer.11
295246292018Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.7

Citation

Dessen P

MFAP5 (microfibril associated protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51289/mfap5